Pulmonary ultrasound in COVID-19 and non-COVID-19 pneumonia in South Africa: An observational study.

Abstract

Background: Pulmonary ultrasound techniques have historically been applied to acute lung diseases to describe lung lesions, particularly in critical care.

Objectives: To explore the role of lung ultrasound (LUS) in hospitalised patients with hypoxaemic pneumonia during the COVID-19 pandemic.

Methods: This was a single-centre prospective, observational study of two groups of adult patients with hypoxaemic pneumonia: those with COVID-19 pneumonia, and those with non-COVID-19 community-acquired pneumonia (CAP). A pulmonologist performed bedside LUS using the Bedside Lung Ultrasound in Emergency (BLUE) protocol, and the findings were verified by an independent study-blinded radiologist.

Results: We enrolled 48 patients with COVID-19 pneumonia and 24 with non-COVID CAP. The COVID-19 patients were significantly older than those with non-COVID CAP (median (interquartile range (IQR)) age 52 (42 - 62.5) years v. 42.5 (36 - 52.5) years, respectively; p=0.007), and had a lower prevalence of HIV infection (25% v. 54%, respectively; p=0.01) and higher prevalences of hypertension (54% v. 7%; p=0.002) and diabetes mellitus (19% v. 8%; p=0.04). In both groups, close to 30% of the patients had severe acute respiratory distress syndrome. A confluent B-line pattern in the right upper lobe was significantly associated with COVID-19 pneumonia compared with the C pattern (relative risk (RR) 3.8; 95% confidence interval (CI) 1.7 - 8.6). Bilateral changes on LUS rather than unilateral or no changes were associated with COVID-19 pneumonia (RR 1.55; 95% CI 1.004 - 2.387). There were no statistically significant differences in median (IQR) lung scores between patients with COVID-19 pneumonia and those with non-COVID CAP (8 (4 - 11.5) v. 7.5 (4.5 - 12.5), respectively). Patients with COVID-19 pneumonia had a higher than predicted mortality. Logistic regression analysis showed a higher Simplified Acute Physiology Score (SAPS II) (RR 1.11; 95% CI 1.02 - 1.21) and a lower total LUS score indicating B lines v. consolidation (RR 0.80; 95% CI 0.65 - 0.99) to be associated with mortality.

Conclusion: Patients with right upper zone consolidation were more likely to have non-COVID CAP than COVID-19 pneumonia. Finding a B pattern as opposed to consolidation was associated with mortality. The admission LUS score was unable to discriminate between COVID-19 and non-COVID CAP, and did not correlate with the ratio of partial pressure of oxygen to fractional inspired oxygen, clinical severity or mortality.

Study synopsis: What the study adds. During the COVID-19 pandemic, in a resource-limited, high-prevalence setting, lung ultrasound (LUS) patterns on admission to hospital were used to distinguish between COVID-19 and other causes in patients with hypoxaemic pneumonia. Patients with right upper zone consolidation were more likely to have non-COVID-19 community-acquired pneumonia (CAP) than COVID-19 pneumonia.Implications of the findings. The admission LUS score was unable to discriminate between COVID-19 pneumonia and non-COVID CAP, and did not correlate with the ratio of partial pressure of oxygen to fractional inspired oxygen, clinical severity or mortality. The pattern was more valuable than the total LUS score in understanding the disease process.