Ying Wu, Chao Wang, Wei Qian, Lieju Wang, Lina Yu, Minming Zhang, Min Yan
{"title":"Temporal lobe dysfunction for comorbid depressive symptoms in postherpetic neuralgia patients.","authors":"Ying Wu, Chao Wang, Wei Qian, Lieju Wang, Lina Yu, Minming Zhang, Min Yan","doi":"10.1093/braincomms/fcaf132","DOIUrl":null,"url":null,"abstract":"<p><p>Depression often occurs concurrently with postherpetic neuralgia (PHN), yet the neural mechanism underlying pain-depression comorbidity remains poorly understood. For this observational study, we recruited 17 depressed PHN patients, 19 non-depressed PHN patients, and 34 healthy controls (HCs) for resting-state functional MRI scans. We firstly investigated the differences in fractional amplitude of low-frequency fluctuation and regional homogeneity values among the three groups to identify a characteristic brain signal of pain-depression comorbidity. Abnormal voxel-wised functional connectivity was then compared across groups and correlated with clinical variables in each group. One-way analysis of covariance results revealed the fractional amplitude of low-frequency fluctuation values differences in the right temporal lobe (TL) and its voxel-wised connectivity with the inferior frontal gyrus (IFG) among three groups. Furthermore, the TL-IFG connectivity was positively associated with the positive emotional scores and life quality scores among depressed PHN patients, but not non-depressed PHN patients and HCs. In summary, these findings highlighted the TL dysfunction in pain-depression comorbidity among PHN population and may offer heuristic cues for central therapeutic targets that could disrupt the pain-depression vicious circle.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 2","pages":"fcaf132"},"PeriodicalIF":4.1000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985680/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/braincomms/fcaf132","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Depression often occurs concurrently with postherpetic neuralgia (PHN), yet the neural mechanism underlying pain-depression comorbidity remains poorly understood. For this observational study, we recruited 17 depressed PHN patients, 19 non-depressed PHN patients, and 34 healthy controls (HCs) for resting-state functional MRI scans. We firstly investigated the differences in fractional amplitude of low-frequency fluctuation and regional homogeneity values among the three groups to identify a characteristic brain signal of pain-depression comorbidity. Abnormal voxel-wised functional connectivity was then compared across groups and correlated with clinical variables in each group. One-way analysis of covariance results revealed the fractional amplitude of low-frequency fluctuation values differences in the right temporal lobe (TL) and its voxel-wised connectivity with the inferior frontal gyrus (IFG) among three groups. Furthermore, the TL-IFG connectivity was positively associated with the positive emotional scores and life quality scores among depressed PHN patients, but not non-depressed PHN patients and HCs. In summary, these findings highlighted the TL dysfunction in pain-depression comorbidity among PHN population and may offer heuristic cues for central therapeutic targets that could disrupt the pain-depression vicious circle.