Temporal lobe dysfunction for comorbid depressive symptoms in postherpetic neuralgia patients.

IF 4.1 Q1 CLINICAL NEUROLOGY
Brain communications Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI:10.1093/braincomms/fcaf132
Ying Wu, Chao Wang, Wei Qian, Lieju Wang, Lina Yu, Minming Zhang, Min Yan
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Abstract

Depression often occurs concurrently with postherpetic neuralgia (PHN), yet the neural mechanism underlying pain-depression comorbidity remains poorly understood. For this observational study, we recruited 17 depressed PHN patients, 19 non-depressed PHN patients, and 34 healthy controls (HCs) for resting-state functional MRI scans. We firstly investigated the differences in fractional amplitude of low-frequency fluctuation and regional homogeneity values among the three groups to identify a characteristic brain signal of pain-depression comorbidity. Abnormal voxel-wised functional connectivity was then compared across groups and correlated with clinical variables in each group. One-way analysis of covariance results revealed the fractional amplitude of low-frequency fluctuation values differences in the right temporal lobe (TL) and its voxel-wised connectivity with the inferior frontal gyrus (IFG) among three groups. Furthermore, the TL-IFG connectivity was positively associated with the positive emotional scores and life quality scores among depressed PHN patients, but not non-depressed PHN patients and HCs. In summary, these findings highlighted the TL dysfunction in pain-depression comorbidity among PHN population and may offer heuristic cues for central therapeutic targets that could disrupt the pain-depression vicious circle.

颞叶功能障碍对带状疱疹后神经痛患者共病抑郁症状的影响
抑郁症通常与带状疱疹后神经痛(PHN)同时发生,但疼痛-抑郁共病的神经机制尚不清楚。在这项观察性研究中,我们招募了17名抑郁症PHN患者,19名非抑郁症PHN患者和34名健康对照(hc)进行静息状态功能MRI扫描。我们首先研究了三组之间低频波动的分数振幅和区域均匀性值的差异,以确定疼痛-抑郁合并症的特征性脑信号。然后比较各组之间异常体素的功能连接,并与每组的临床变量相关。单向协方差分析结果揭示了三组右颞叶(TL)低频波动值的分数幅值差异及其与额下回(IFG)的体素连接。此外,在抑郁的PHN患者中,TL-IFG连通性与积极情绪评分和生活质量评分呈正相关,而非抑郁的PHN患者和hc患者则没有。总之,这些发现强调了在PHN人群中疼痛-抑郁合并症中的TL功能障碍,并可能为打破疼痛-抑郁恶性循环的中心治疗靶点提供启发式线索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
7.00
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