{"title":"Next generation pneumococcal vaccines for children and adults.","authors":"Rosario Menendez, Maria Garces-Sanchez","doi":"10.1055/a-2588-6965","DOIUrl":null,"url":null,"abstract":"<p><p>Streptococcus pneumoniae remains one of the leading causes of mortality and morbidity in children and in the elderly worldwide. Pneumococcal conjugated vaccines (PCVs) have reduced invasive and noninvasive pneumococcal disease in children and adults. However, challenges persist due to serotype replacement, epidemiological diversity and global inequalities in vaccine access. The future of PCVs is structured around three major areas of innovation: expanding antigenic coverage, developing serotype-independent formulations and introducing advanced technological platforms such as the Multiple Antigen Presenting System (MAPS). The challenge is double to better improve immunogenicity beyond serotypes and to extend the global impact of vaccines with more equitable and effective global rates of vaccination.</p>","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in respiratory and critical care medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2588-6965","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Streptococcus pneumoniae remains one of the leading causes of mortality and morbidity in children and in the elderly worldwide. Pneumococcal conjugated vaccines (PCVs) have reduced invasive and noninvasive pneumococcal disease in children and adults. However, challenges persist due to serotype replacement, epidemiological diversity and global inequalities in vaccine access. The future of PCVs is structured around three major areas of innovation: expanding antigenic coverage, developing serotype-independent formulations and introducing advanced technological platforms such as the Multiple Antigen Presenting System (MAPS). The challenge is double to better improve immunogenicity beyond serotypes and to extend the global impact of vaccines with more equitable and effective global rates of vaccination.
期刊介绍：
The journal focuses on new diagnostic and therapeutic procedures, laboratory studies, genetic breakthroughs, pathology, clinical features and management as related to such areas as asthma and other lung diseases, critical care management, cystic fibrosis, lung and heart transplantation, pulmonary pathogens, and pleural disease as well as many other related disorders.The journal focuses on new diagnostic and therapeutic procedures, laboratory studies, genetic breakthroughs, pathology, clinical features and management as related to such areas as asthma and other lung diseases, critical care management, cystic fibrosis, lung and heart transplantation, pulmonary pathogens, and pleural disease as well as many other related disorders.
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