Alternations in morphometric similarity network in mesial temporal epilepsy correlate to neuroinflammatory pathway gene transcriptions.

IF 1.2 Q4 CLINICAL NEUROLOGY

Acta Epileptologica Pub Date : 2025-03-04 DOI:10.1186/s42494-025-00208-4

Lu Lu, Chenyang Zhao, Weihao Liao, Peiyu Wang, Yingying Zhang, Dongmei An, Xintong Wu, Hesheng Zhang, Ping Jiang, Yaohui He, Jinpeng Niu, Wei Li, Kangjia Chen, Su Lui, Yu Zhao, Qiyong Gong, Bo Wang, Wei Liao, Josemir W Sander, Lin Chen, Dong Zhou

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Abstract

Background: Mesial temporal lobe epilepsy (mTLE) is the most common form of focal epilepsy, often associated with hippocampal sclerosis. Increasing evidence suggests the pivotal role of neuroinflammation in mTLE onset and progression.

Methods: We used morphometric similarity network (MSN) analysis and the Allen Human Brain Atlas (AHBA) database to investigate structural changes between mTLE and healthy controls, as well as correlation with inflammation-related gene expression.

Results: We identified widespread alterations across the frontal and parietal lobes and cingulate cortex linked to neuroinflammatory genes such as PRR5, SMAD3, and IRF3. This correlation was even more pronounced in mTLE patients with hippocampal sclerosis compared to those without. Enrichment analysis highlighted pathways related to neurodevelopment and neurodegeneration, supporting a bidirectional link between mTLE and neurodegenerative diseases.

Conclusions: These findings suggest that brain-wide macroscopic morphometric alternations in mTLE are correlated to the neuroinflammation process. It provides circumstantial evidence from a new perspective to support the bidirectional link between mTLE and neurodegenerative diseases.

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内侧颞叶癫痫中形态相似性网络的改变与神经炎症通路基因转录相关。

背景：内侧颞叶癫痫（mTLE）是局灶性癫痫最常见的形式，通常与海马硬化有关。越来越多的证据表明，神经炎症在mTLE的发病和进展中起着关键作用。方法：采用形态学相似性网络（MSN）分析和Allen人脑图谱（AHBA）数据库研究mTLE与健康对照组的结构变化及其与炎症相关基因表达的相关性。结果：我们确定了与神经炎症基因（如PRR5、SMAD3和IRF3）相关的前额叶、顶叶和扣带皮层的广泛改变。与没有海马硬化的mTLE患者相比，这种相关性更为明显。富集分析强调了与神经发育和神经退行性疾病相关的通路，支持mTLE与神经退行性疾病之间的双向联系。结论：这些发现提示mTLE的全脑宏观形态学改变与神经炎症过程相关。从一个新的角度为mTLE与神经退行性疾病之间的双向联系提供了间接证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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