Investigating P M 2.5 Oxidative Potential and Its Association with Chemical Constituents Measured outside of Urban Residences in Three Metropolitan Cities of India.

IF 2.4 Q1 Medicine
Journal of Health and Pollution Pub Date : 2024-10-29 eCollection Date: 2024-12-01 DOI:10.1289/JHP1007
Shreya Dubey, Prince Vijay, Nagendra Raparthi, Harish C Phuleria
{"title":"<ArticleTitle xmlns:ns0=\"http://www.w3.org/1998/Math/MathML\">Investigating <ns0:math><ns0:mrow><ns0:mi>P</ns0:mi> <ns0:mrow> <ns0:msub><ns0:mrow><ns0:mi>M</ns0:mi></ns0:mrow> <ns0:mrow><ns0:mrow><ns0:mn>2.5</ns0:mn></ns0:mrow> </ns0:mrow> </ns0:msub> </ns0:mrow> </ns0:mrow> </ns0:math> Oxidative Potential and Its Association with Chemical Constituents Measured outside of Urban Residences in Three Metropolitan Cities of India.","authors":"Shreya Dubey, Prince Vijay, Nagendra Raparthi, Harish C Phuleria","doi":"10.1289/JHP1007","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Redox-active potent species present in fine particulate matter [PM <math><mrow><mo>≤</mo> <mn>2.5</mn> <mspace></mspace> <mi>μ</mi> <mi>m</mi></mrow> </math> in aerodynamic diameter ( <math> <mrow> <mrow> <msub> <mrow><mrow><mi>PM</mi></mrow> </mrow> <mrow><mrow><mn>2.5</mn></mrow> </mrow> </msub> </mrow> </mrow> </math> )] have been suggested as one of the major sources of oxidative stress- and health-related disorders in the urban population.</p><p><strong>Objectives: </strong>Our objective was to determine <math> <mrow> <mrow> <msub> <mrow><mrow><mi>PM</mi></mrow> </mrow> <mrow><mrow><mn>2.5</mn></mrow> </mrow> </msub> </mrow> </mrow> </math> oxidative potential (OP) in urban residential neighborhoods having different sources of <math> <mrow> <mrow> <msub> <mrow><mrow><mi>PM</mi></mrow> </mrow> <mrow><mrow><mn>2.5</mn></mrow> </mrow> </msub> </mrow> </mrow> </math> (traffic emissions, commercial, and residential activities) in three metropolitan Indian cities.</p><p><strong>Methods: </strong>We investigated the neighborhood and seasonal variation in <math> <mrow> <mrow> <msub> <mrow><mrow><mi>PM</mi></mrow> </mrow> <mrow><mrow><mn>2.5</mn></mrow> </mrow> </msub> </mrow> </mrow> </math> OP across three metropolitan cities (Delhi, Mumbai, and Bengaluru) in India. Low-cost samplers were used to collect <math> <mrow> <mrow> <msub> <mrow><mrow><mi>PM</mi></mrow> </mrow> <mrow><mrow><mn>2.5</mn></mrow> </mrow> </msub> </mrow> </mrow> </math> outside balconies, ground floors, and first floors of residential buildings for 24 h. We used acellular assays, including dithiothreitol (DTT) and ascorbic acid (AA), to examine the particle toxicity. Bivariate and multiple linear regression analyses were conducted to examine the association of OP with the analyzed PM constituents.</p><p><strong>Results: </strong>The extrinsic <math> <mrow> <mrow> <msup> <mrow><mrow><mtext>OP</mtext></mrow> </mrow> <mrow><mrow><mtext>DTTv</mtext></mrow> </mrow> </msup> </mrow> </mrow> </math> levels, were comparable between the cities, with the highest levels observed in Delhi ( <math><mrow><mtext>mean</mtext> <mo>±</mo> <mtext>standard deviation</mtext></mrow> </math> : <math><mrow><mn>3.82</mn> <mo>±</mo> <mn>1.56</mn> <mrow> <msup><mrow><mtext> nmol</mtext> <mo>/</mo> <mtext>min</mtext> <mo>/</mo> <mi>m</mi></mrow> <mrow><mn>3</mn></mrow> </msup> </mrow> </mrow> </math> ), exceeding those in Mumbai and Bengaluru by a factor of 1.03 and 1.21, respectively. For intrinsic OP, ( <math> <mrow> <mrow> <msup> <mrow><mrow><mtext>OP</mtext></mrow> </mrow> <mrow><mrow><mtext>DTTm</mtext></mrow> </mrow> </msup> </mrow> </mrow> </math> ), Bengaluru exhibited the maximum toxicity, followed by Mumbai and Delhi. Bengaluru demonstrated significant OP variation compared with both Delhi and Mumbai. <math> <mrow> <mrow> <msup> <mrow><mrow><mtext>OP</mtext></mrow> </mrow> <mrow><mrow><mtext>AA</mtext></mrow> </mrow> </msup> </mrow> </mrow> </math> showed comparable trends in both intrinsic and extrinsic variation. Further, on comparing intra-urban variability, <math> <mrow> <mrow> <msup> <mrow><mrow><mtext>OP</mtext></mrow> </mrow> <mrow><mrow><mtext>DTTv</mtext></mrow> </mrow> </msup> </mrow> </mrow> </math> was highest in all cities in the high-traffic neighborhoods, ranging from <math><mrow><mn>5.13</mn> <mtext> to </mtext> <mn>4.22</mn> <mrow> <msup><mrow><mtext> nmol</mtext> <mo>/</mo> <mtext>min</mtext> <mo>/</mo> <mi>m</mi></mrow> <mrow><mn>3</mn></mrow> </msup> </mrow> </mrow> </math> . Bengaluru residential neighborhoods were <math><mrow><mo>∼</mo> <mn>4</mn> <mtext> and </mtext> <mn>6</mn></mrow> </math> times higher in <math> <mrow> <mrow> <msup> <mrow><mrow><mtext>OP</mtext></mrow> </mrow> <mrow><mrow><mtext>AAm</mtext></mrow> </mrow> </msup> </mrow> </mrow> </math> compared with Delhi and Mumbai residential neighborhoods, respectively. Among residential neighborhoods, the coefficient of divergence (COD) showed <math><mrow><mo>∼</mo> <mn>1.5</mn> <mtext> times</mtext></mrow> </math> higher heterogeneity in <math> <mrow> <mrow> <msup> <mrow><mrow><mtext>OP</mtext></mrow> </mrow> <mrow><mrow><mtext>AAv</mtext></mrow> </mrow> </msup> </mrow> </mrow> </math> than <math> <mrow> <mrow> <msup> <mrow><mrow><mtext>OP</mtext></mrow> </mrow> <mrow><mrow><mtext>DTTv</mtext></mrow> </mrow> </msup> </mrow> </mrow> </math> . Carbonaceous fractions and a few transition elements were strongly correlated ( <math><mrow><mi>p</mi> <mo><</mo> <mn>0.05</mn></mrow> </math> ) with OP assays. In Mumbai, comparable <math> <mrow> <mrow> <msup> <mrow><mrow><mtext>OP</mtext></mrow> </mrow> <mrow><mrow><mtext>DTTv</mtext></mrow> </mrow> </msup> </mrow> </mrow> </math> levels were observed in both seasons, winter and summer, suggesting that toxicity is more likely influenced by the primary-originated traffic aerosols. Water-soluble organic carbon, cobalt (Co), and vanadium (V) were the primary contributors to reactive oxygen species activity.</p><p><strong>Discussion: </strong>Our study reveals that PM toxicity outside of residential homes in traffic-dominated neighborhoods is significant compared with other neighborhoods across all metropolitan cities. This emphasizes the potential health risks associated with PM originating from traffic sources. https://doi.org/10.1289/JHP1007.</p>","PeriodicalId":52138,"journal":{"name":"Journal of Health and Pollution","volume":"12 1-4","pages":"017004"},"PeriodicalIF":2.4000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061257/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Health and Pollution","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1289/JHP1007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Redox-active potent species present in fine particulate matter [PM 2.5 μ m in aerodynamic diameter ( PM 2.5 )] have been suggested as one of the major sources of oxidative stress- and health-related disorders in the urban population.

Objectives: Our objective was to determine PM 2.5 oxidative potential (OP) in urban residential neighborhoods having different sources of PM 2.5 (traffic emissions, commercial, and residential activities) in three metropolitan Indian cities.

Methods: We investigated the neighborhood and seasonal variation in PM 2.5 OP across three metropolitan cities (Delhi, Mumbai, and Bengaluru) in India. Low-cost samplers were used to collect PM 2.5 outside balconies, ground floors, and first floors of residential buildings for 24 h. We used acellular assays, including dithiothreitol (DTT) and ascorbic acid (AA), to examine the particle toxicity. Bivariate and multiple linear regression analyses were conducted to examine the association of OP with the analyzed PM constituents.

Results: The extrinsic OP DTTv levels, were comparable between the cities, with the highest levels observed in Delhi ( mean ± standard deviation : 3.82 ± 1.56  nmol / min / m 3 ), exceeding those in Mumbai and Bengaluru by a factor of 1.03 and 1.21, respectively. For intrinsic OP, ( OP DTTm ), Bengaluru exhibited the maximum toxicity, followed by Mumbai and Delhi. Bengaluru demonstrated significant OP variation compared with both Delhi and Mumbai. OP AA showed comparable trends in both intrinsic and extrinsic variation. Further, on comparing intra-urban variability, OP DTTv was highest in all cities in the high-traffic neighborhoods, ranging from 5.13  to  4.22  nmol / min / m 3 . Bengaluru residential neighborhoods were 4  and  6 times higher in OP AAm compared with Delhi and Mumbai residential neighborhoods, respectively. Among residential neighborhoods, the coefficient of divergence (COD) showed 1.5  times higher heterogeneity in OP AAv than OP DTTv . Carbonaceous fractions and a few transition elements were strongly correlated ( p < 0.05 ) with OP assays. In Mumbai, comparable OP DTTv levels were observed in both seasons, winter and summer, suggesting that toxicity is more likely influenced by the primary-originated traffic aerosols. Water-soluble organic carbon, cobalt (Co), and vanadium (V) were the primary contributors to reactive oxygen species activity.

Discussion: Our study reveals that PM toxicity outside of residential homes in traffic-dominated neighborhoods is significant compared with other neighborhoods across all metropolitan cities. This emphasizes the potential health risks associated with PM originating from traffic sources. https://doi.org/10.1289/JHP1007.

调查印度三个大城市城市住宅外pm2.5氧化电位及其与化学成分的关系。
背景:细颗粒物[空气动力学直径PM≤2.5 μ m (PM 2.5)]中存在的氧化还原活性强效物质已被认为是城市人群中氧化应激和健康相关疾病的主要来源之一。目的:我们的目的是确定在印度三个大都市中具有不同PM 2.5来源(交通排放、商业和住宅活动)的城市居民区的PM 2.5氧化电位(OP)。方法:我们调查了印度三个大城市(德里、孟买和班加罗尔)PM 2.5 OP的邻里和季节变化。采用低成本采样器采集住宅阳台、底层和一楼外24小时的PM 2.5。采用非细胞测定法,包括二硫代索糖醇(DTT)和抗坏血酸(AA),检测颗粒毒性。进行了双变量和多元线性回归分析,以检验OP与所分析的PM成分的关系。结果:外源性OP DTTv水平在城市之间具有可比性,德里的水平最高(平均值±标准差:3.82±1.56 nmol / min / m 3),分别超过孟买和班加罗尔的1.03和1.21倍。对于内在OP, (OP DTTm),班加罗尔表现出最大的毒性,其次是孟买和德里。与德里和孟买相比,班加罗尔表现出显著的OP差异。OP AA表现出可比较的内在和外在变化趋势。此外,在比较城市内部变化时,所有城市的高交通街区的OP DTTv最高,范围为5.13至4.22 nmol / min / m3。与德里和孟买的居民区相比,班加罗尔居民区的空气污染指数分别高出4倍和6倍。在居民区中,城区AAv的差异系数(COD)是城区DTTv的1.5倍。碳质组分和少数过渡元素与OP测定有很强的相关性(p 0.05)。在孟买,冬季和夏季两个季节都观察到相当的臭氧DTTv水平,这表明毒性更可能受到主要来源的交通气溶胶的影响。水溶性有机碳、钴(Co)和钒(V)是活性氧活性的主要贡献者。讨论:我们的研究表明,与所有大都市的其他社区相比,交通主导社区住宅外的PM毒性显着。这强调了与来自交通来源的PM相关的潜在健康风险。https://doi.org/10.1289/JHP1007。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Health and Pollution
Journal of Health and Pollution Medicine-Public Health, Environmental and Occupational Health
自引率
0.00%
发文量
0
审稿时长
18 weeks
期刊介绍: The Journal of Health and Pollution (JH&P) was initiated with funding from the European Union and World Bank and continues to be a Platinum Open Access Journal. There are no publication or viewing charges. That is, there are no charges to readers or authors. Upon peer-review and acceptance, all articles are made available online. The high-ranking editorial board is comprised of active members who participate in JH&P submissions and editorial policies. The Journal of Health and Pollution welcomes manuscripts based on original research as well as findings from re-interpretation and examination of existing data. JH&P focuses on point source pollution, related health impacts, environmental control and remediation technology. JH&P also has an interest in ambient and indoor pollution. Pollutants of particular interest include heavy metals, pesticides, radionuclides, dioxins, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), air particulates (PM10 and PM2.5), and other severe and persistent toxins. JH&P emphasizes work relating directly to low and middle-income countries, however relevant work relating to high-income countries will be considered on a case-by-case basis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信