Extracellular Volume Derived from Equilibrium CT for the Prediction of Survival Outcomes in Patients with Pancreatic Ductal Adenocarcinoma.

Abstract

ObjectiveTo assess the efficiency of extracellular volume (ECV) derived from equilibrium computed tomography (CT) in predicting recurrence-free survival (RFS) and overall survival (OS) after R0 resection of pancreatic ductal adenocarcinoma (PDAC).MethodsThis retrospective study included 83 patients who underwent CT and R0 resection between January 2016 and September 2023. The pattern of tumor recurrence and prognosis were recorded for each patient. Tumor recurrence was classified into three groups: isolated local recurrence group, distant recurrence group and censored group. The associations between the CT-ECV and clinicopathological features and recurrence pattern of PDAC were evaluated by chi-squared test. Multivariable Cox proportional-hazards models were conducted to evaluate the effects of clinical factors, CT features and CT-ECV on RFS and OS.ResultsThe median RFS and OS were 10.7 and 17.1 months, respectively. On multivariate analysis, the CT-ECV and adjacent organ invasion were found to be associated with RFS (HR, 0.968, P = .017; HR, 0.453; P = .006), and only the CT-ECV was an independent prognostic factor for OS (HR, 0.968; P = .022). Low CT-ECV group was significantly associated with elevated CA19-9, larger tumor size, G3 (tumor grade) and II/III (AJCC tumor stage) (P < .05). In the recurrence pattern analysis, the CT-ECV did not exhibit an association between local recurrence and non-local recurrence groups (P = .455), while patients in the low CT-ECV group were more inclined to experience distant recurrence after curative surgery (P = .037).ConclusionsCT-ECV determined by equilibrium contrast-enhanced CT was a useful imaging biomarker for predicting distant recurrence and survival in resectable PDAC patients, which may facilitate further risk stratification and personalized care.