Association between frailty and oral function in rheumatoid arthritis patients: A multi-center, observational study.

IF 1.1 Q4 RHEUMATOLOGY
Archives of rheumatology Pub Date : 2025-03-17 eCollection Date: 2025-03-01 DOI:10.46497/ArchRheumatol.2025.11039
Yasumori Sobue, Mochihito Suzuki, Yoshifumi Ohashi, Ryo Sato, Yusuke Ohno, Junya Hasegawa, Takaya Sugiura, Kenya Terabe, Shuji Asai, Shiro Imagama
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Abstract

Objectives: This study aims to investigate the association between frailty and oral function in rheumatoid arthritis (RA) patients and to identify practical markers for early frailty detection and potential intervention strategies.

Patients and methods: A multi-center observational cohort study (T-FLAG) included a total of 661 RA patients (186 males, 475 females; mean age: 68.5±13.5 years; range, 18 to 100 years) between June 2023 and August 2023. Frailty was assessed using the Kihon Checklist (KCL) (frailty: score ≥8). Oral function scores were based on Question 13 ("difficulty eating hard foods"), Question 14 ("choking"), and Question 15 ("dry mouth") of the KCL. Receiver operating characteristic (ROC) curves were generated to assess the association between frailty and oral function scores. Multivariate logistic regression was used to analyze factors associated with oral function.

Results: Among the 661 participants, 39.5% were frail. Frailty rates tended to increase with increasing oral function scores. The optimal cut-off score for oral function corresponding to frailty was 2 points, with a specificity of 89.2% and a sensitivity of 54.8%. Multivariate analysis identified age and Health Assessment Questionnaire-Disability Index (HAQ-DI) as significant factors associated with oral function decline (i.e., a total score of ≥2 for Questions 13-15 of the KCL).

Conclusion: Frailty is strongly associated with oral function decline in RA patients. This finding highlights the importance of monitoring the oral function of RA patients, since it not only reflects physical function, but also serves as a potential marker of frailty. Targeted interventions to improve oral function may play a vital role in reducing frailty risk and enhancing the overall well-being of RA patients.

类风湿关节炎患者虚弱与口腔功能的关系:一项多中心观察性研究。
目的:本研究旨在探讨类风湿关节炎(RA)患者虚弱与口腔功能之间的关系,并确定早期虚弱检测和潜在干预策略的实用标志物。患者和方法:一项多中心观察队列研究(T-FLAG)共纳入661例RA患者(男性186例,女性475例;平均年龄:68.5±13.5岁;从2023年6月到2023年8月。虚弱程度采用Kihon Checklist (KCL)进行评估(虚弱程度:评分≥8)。口腔功能评分基于KCL的第13题(“难以进食硬食物”)、第14题(“窒息”)和第15题(“口干”)。生成受试者工作特征(ROC)曲线来评估虚弱和口腔功能评分之间的关系。采用多因素logistic回归分析口腔功能的相关因素。结果:661名参与者中,39.5%身体虚弱。衰弱率倾向于随着口腔功能评分的增加而增加。口腔功能衰弱对应的最佳临界值为2分,特异性为89.2%,敏感性为54.8%。多因素分析发现,年龄和健康评估问卷-残疾指数(HAQ-DI)是口腔功能下降的重要因素(即,KCL 13-15题总分≥2)。结论:虚弱与RA患者口腔功能下降密切相关。这一发现强调了监测RA患者口腔功能的重要性,因为它不仅反映了身体功能,而且还可以作为虚弱的潜在标志。有针对性的干预措施改善口腔功能可能在降低衰弱风险和提高RA患者的整体幸福感方面发挥重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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