Hyperuricemia and the risk of stroke incidence and mortality: A systematic review and meta-analysis.

IF 1.1 Q4 RHEUMATOLOGY
Archives of rheumatology Pub Date : 2025-03-17 eCollection Date: 2025-03-01 DOI:10.46497/ArchRheumatol.2025.10808
Haiyan Jiang, Yunyi Su, Ruixue Liu, Xinyi Xu, Qi Xu, Jie Yang, Yapeng Lin
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Abstract

Objectives: The relationship between hyperuricemia (HUA) and stroke remains controversial. In this systematic review, we discuss the association between HUA and stroke.

Materials and methods: The PubMed, Embase, Web of Science, and Cochrane Library were searched from their earliest records to March 13th, 2024, and additional papers were identified through a manual search. Prospective studies that provided a multivariate-adjusted estimate of the association between HUA and risk of stroke incidence and mortality, represented as relative risks (RRs) with 95% confidence intervals (CIs), were eligible.

Results: A total of 22 studies including 770,532 adults were eligible and included. Hyperuricemia was associated with a significantly increasing risk of both stroke incidence (pooled RR, 1.42; 95% CI, 1.31-1.53) and stroke mortality (pooled RR, 1.53; 95% CI, 1.18-1.99) in our meta-analyses. Relative risk of stroke incidence was as follows: females (pooled RR, 1.67; 95% CI, 1.44-1.92) and males (pooled RR, 1.13; 95% CI, 1.02-1.25). Relative risk of mortality was as follows: female (pooled RR, 1.41; 95% CI, 1.31-1.52) and males (pooled RR, 1.27; 95% CI, 1.20-1.34). For the risk of stroke mortality, the association between HUA and ischemic stroke (pooled RR, 1.39; 95% CI, 1.31-1.47) was more significant than that of hemorrhagic stroke (pooled RR, 1.13; 95% CI, 1.02-1.26).

Conclusion: Our study confirms an association between HUA and risk of stroke, which is more pronounced in females.

高尿酸血症与卒中发病率和死亡率的风险:一项系统回顾和荟萃分析。
目的:高尿酸血症(HUA)与脑卒中之间的关系仍然存在争议。在这篇系统综述中,我们讨论了HUA与脑卒中之间的关系。材料和方法:检索PubMed、Embase、Web of Science和Cochrane Library,从最早的记录到2024年3月13日,并通过人工检索确定其他论文。提供HUA与卒中发病率和死亡率风险之间关联的多变量调整的前瞻性研究,以95%置信区间(ci)的相对风险(rr)表示,符合条件。结果:共纳入22项研究,包括770,532名成人。高尿酸血症与卒中发生率的显著增加相关(合并RR, 1.42;95% CI, 1.31-1.53)和卒中死亡率(合并RR, 1.53;95% CI, 1.18-1.99)。卒中发生的相对风险如下:女性(合并RR, 1.67;95% CI, 1.44-1.92)和男性(合并RR, 1.13;95% ci, 1.02-1.25)。死亡的相对风险如下:女性(合并RR, 1.41;95% CI, 1.31-1.52)和男性(合并RR, 1.27;95% ci, 1.20-1.34)。对于卒中死亡风险,HUA与缺血性卒中之间的关联(合并RR, 1.39;95% CI, 1.31-1.47)比出血性卒中更显著(合并RR, 1.13;95% ci, 1.02-1.26)。结论:我们的研究证实了HUA与卒中风险之间的关联,这在女性中更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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