[The role of neurohormonal regulatory factors in the violation of the motor evacuation function of the duodenum in chronic duodenal insufficiency].

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Terapevticheskii Arkhiv Pub Date : 2025-03-26 DOI:10.26442/00403660.2025.02.203121

Y M Vakhrushev, M S Busygina

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引用次数: 0

Abstract

Aim: To study the interaction of hormonal factors and indicators of vegetative homeostasis in violation of the motor evacuation function of the duodenum in chronic duodenal insufficiency (CDI).

Materials and methods: 70 patients with CDI were under observation. The average age of patients was 35.7±11.4 years, women were 32 (45.7%), men - 38 (54.3%). The control group included 31 healthy individuals [average age 39.1±12.3 years; there were 15 women (48.3%), 16 men (51.7%)]. Cardiorhythmographic examination and analysis of heart rate variability with the "Varicard 2.51" complex were used to study the ANS. To study the intramural nervous apparatus of the duodenum, a biopsy piece of its wall from the lower horizontal section was examined. Electrochemiluminescence analysis made it possible to determine the content of gastrin, insulin, cortisol, and somatostatin in the blood. To diagnose motor disorders of the gastroduodenal zone, peripheral electrogastroenterography was performed using the gastroenteromonitor GEM-01 "Gastroscan-GEM".

Results: In patients with CDI, in addition to changes in the clinical and electrophysiological picture, changes in the vegetative status were revealed. This condition correlates with the following electrophysiological signs in CDI - hypomotor duodenum leads to a greater increase in the ratio P_i/P_i_{+ 1} stomach / duodenum after food stimulation (17.43±2.46) in this group of patients (p=0.000). The study of the basal hormone content in CDI showed a significant increase in gastrin, cortisol and a decrease in insulin and somatostatin in comparison with the control group. The relationship between them and vegetative-electrophysiological indicators is revealed.

Conclusion: Comprehensive studies of myoelectric activity, the functional state of the autonomic nervous system and hormonal regulatory factors, followed by the analysis of multidimensional statistics data, revealed new pathophysiological patterns in duodenal motility disorders in CDI.

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[神经激素调节因子在慢性十二指肠功能不全中十二指肠运动排泄功能破坏中的作用]。

目的：探讨慢性十二指肠功能不全（CDI）时，内分泌因子与营养稳态指标的相互作用对十二指肠运动排泄功能的影响。材料与方法：对70例CDI患者进行观察。患者平均年龄35.7±11.4岁，女性32岁（45.7%），男性- 38岁（54.3%）。对照组健康者31例，平均年龄39.1±12.3岁；其中女性15例（48.3%），男性16例（51.7%）。采用“Varicard 2.51”复合体进行心率变异性分析和心电图检查，并从十二指肠下部水平切面取十二指肠壁活检片研究十二指肠壁内神经装置。电化学发光分析使测定血液中胃泌素、胰岛素、皮质醇和生长抑素的含量成为可能。为了诊断胃十二指肠区运动障碍，采用胃肠监测仪GEM-01“Gastroscan-GEM”进行外周胃肠电图检查。结果：在CDI患者中，除了临床和电生理图像的变化外，还显示了植物状态的变化。此病与CDI的以下电生理征象相关——十二指肠运动低下导致本组患者食物刺激后胃/十二指肠Pi/Pi + 1比值（17.43±2.46）升高较大（p=0.000）。基础激素含量的研究显示，与对照组相比，CDI组胃泌素、皮质醇显著升高，胰岛素和生长抑素显著降低。揭示了它们与植物电生理指标之间的关系。结论：通过对肌电活动、自主神经系统功能状态、激素调节因子的综合研究，结合多维统计数据分析，揭示了CDI十二指肠运动障碍新的病理生理模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.