Single nucleotide polymorphism analysis of 3'UTR rs713041 of Glutathione peroxidase 4 association with susceptibility to oral premalignant disorders.

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2025-04-21 DOI:10.1007/s10006-025-01380-0

Usha Subbiah, Nihala Sidhic

{"title":"Single nucleotide polymorphism analysis of 3'UTR rs713041 of Glutathione peroxidase 4 association with susceptibility to oral premalignant disorders.","authors":"Usha Subbiah, Nihala Sidhic","doi":"10.1007/s10006-025-01380-0","DOIUrl":null,"url":null,"abstract":"Purpose: Oral potentially malignant disorders (OPMDs) affect the oral mucosa and increase the risk of oral cancer. Glutathione peroxidase 4 (GPX4), a key antioxidant mediator and regulator of ferroptosis, has garnered significant attention in cancer research. This study is to investigate the association between the single nucleotide polymorphism GPX4 3'UTR rs713041 and oral premalignancy disorders.Methods: The rs713041of GPX4 were analysed using PCR-RFLP IN 600 subjects including OSMF, leukoplakia and healthy controls along with their habitual factors.Results: Chewing and smoking habits were present in 52% and 69% of OSMF cases, and 62% and 57% of leukoplakia cases, respectively. Disease prevalence was 78% in males and 59% in females for OSMF, and 22% in males and 26% in females for leukoplakia. The allele frequency distribution for OSMF did not significantly deviate from Hardy-Weinberg equilibrium. The heterozygous TC genotype in OSMF showed a significant association with an odds ratio of 2.42 (CI: 1.58-3.72, P = 0.00) compared to controls.Conclusion: The GPX4 3'UTR T/C carrier genotype is associated with an increased risk of OSMF and leukoplakia. This genotype could serve as a predictive marker for the risk of oral premalignancy disorders.Clinical trail number: Not applicable.","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"89"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral and Maxillofacial Surgery-Heidelberg","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s10006-025-01380-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Oral potentially malignant disorders (OPMDs) affect the oral mucosa and increase the risk of oral cancer. Glutathione peroxidase 4 (GPX4), a key antioxidant mediator and regulator of ferroptosis, has garnered significant attention in cancer research. This study is to investigate the association between the single nucleotide polymorphism GPX4 3'UTR rs713041 and oral premalignancy disorders.

Methods: The rs713041of GPX4 were analysed using PCR-RFLP IN 600 subjects including OSMF, leukoplakia and healthy controls along with their habitual factors.

Results: Chewing and smoking habits were present in 52% and 69% of OSMF cases, and 62% and 57% of leukoplakia cases, respectively. Disease prevalence was 78% in males and 59% in females for OSMF, and 22% in males and 26% in females for leukoplakia. The allele frequency distribution for OSMF did not significantly deviate from Hardy-Weinberg equilibrium. The heterozygous TC genotype in OSMF showed a significant association with an odds ratio of 2.42 (CI: 1.58-3.72, P = 0.00) compared to controls.

Conclusion: The GPX4 3'UTR T/C carrier genotype is associated with an increased risk of OSMF and leukoplakia. This genotype could serve as a predictive marker for the risk of oral premalignancy disorders.

Clinical trail number: Not applicable.

查看原文本刊更多论文

谷胱甘肽过氧化物酶4基因3′utr rs713041与口腔癌前病变易感性的单核苷酸多态性分析

目的：口腔潜在恶性疾病（OPMDs）影响口腔黏膜，增加口腔癌的发生风险。谷胱甘肽过氧化物酶4 （Glutathione peroxidase 4, GPX4）是铁凋亡的重要抗氧化介质和调节因子，在癌症研究中受到了广泛关注。本研究旨在探讨GPX4 3'UTR rs713041单核苷酸多态性与口腔恶性前病变的关系。方法：采用PCR-RFLP方法对600例OSMF、白斑和健康对照者的GPX4基因rs713041及其习惯因素进行分析。结果：咀嚼和吸烟习惯分别在52%和69%的OSMF病例和62%和57%的白斑病例中存在。OSMF患病率为男性78%，女性59%，白斑患病率为男性22%，女性26%。OSMF的等位基因频率分布没有明显偏离Hardy-Weinberg平衡。与对照组相比，OSMF中TC基因型的杂合性显著相关，比值比为2.42 （CI: 1.58 ~ 3.72, P = 0.00）。结论：GPX4 3′utr T/C携带者基因型与OSMF和白斑发病风险增加相关。该基因型可作为口腔恶性前病变风险的预测标志物。临床试验号：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oral and Maxillofacial Surgery-Heidelberg DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.20

自引率

5.60%

发文量

118

期刊介绍： Oral & Maxillofacial Surgery founded as Mund-, Kiefer- und Gesichtschirurgie is a peer-reviewed online journal. It is designed for clinicians as well as researchers.The quarterly journal offers comprehensive coverage of new techniques, important developments and innovative ideas in oral and maxillofacial surgery and interdisciplinary aspects of cranial, facial and oral diseases and their management. The journal publishes papers of the highest scientific merit and widest possible scope on work in oral and maxillofacial surgery as well as supporting specialties. Practice-oriented articles help improve the methods used in oral and maxillofacial surgery.Every aspect of oral and maxillofacial surgery is fully covered through a range of invited review articles, clinical and research articles, technical notes, abstracts, and case reports. Specific topics are: aesthetic facial surgery, clinical pathology, computer-assisted surgery, congenital and craniofacial deformities, dentoalveolar surgery, head and neck oncology, implant dentistry, oral medicine, orthognathic surgery, reconstructive surgery, skull base surgery, TMJ and trauma.Time-limited reviewing and electronic processing allow to publish articles as fast as possible. Accepted articles are rapidly accessible online.Clinical studies submitted for publication have to include a declaration that they have been approved by an ethical committee according to the World Medical Association Declaration of Helsinki 1964 (last amendment during the 52nd World Medical Association General Assembly, Edinburgh, Scotland, October 2000). Experimental animal studies have to be carried out according to the principles of laboratory animal care (NIH publication No 86-23, revised 1985).