Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study.

IF 3 2区医学 Q1 EMERGENCY MEDICINE

Scandinavian Journal of Trauma Resuscitation & Emergency Medicine Pub Date : 2025-05-01 DOI:10.1186/s13049-025-01395-2

Nai-Chen Shih, Han-Wei Yeh, Shun-Fa Yang, Yu-Hsun Wang, Chung-Hsien Chaou, Chao-Bin Yeh

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引用次数: 0

Abstract

Background: This study aims to compare the mortality rates of OHCA patients with and without COVID-19 infection across different follow-up periods and explores the factors may play a significant role in determining OHCA outcomes.

Methods: This study utilized data from the US Collaborative Network in TriNetX. A total of 25,271 hospitalized OHCA patients were recruited from records spanning from January 1, 2020, to December 31, 2023. Study population divided into two groups, COVID-19 positive and COVID-19 negative groups. The mortality risk of the two groups was observed based on different follow-up periods. Subgroup analyses on sex, age, antivirals use, COVID-19 virus variant epidemic period were also conducted.

Results: Our study included 2,776 patients in each group (COVID vs. non-COVID). The primary outcome was mortality at 14-day and 90-day follow-ups. COVID-19 patients had a lower 14-day mortality (HR 0.82, 95% CI: 0.76-0.88) but higher 90-day mortality (HR 1.16, 95% CI: 1.09-1.24) compared to non-COVID-19 patients. Secondary outcomes included higher mortality in COVID-19 patients under 65, and this trend persisted in those aged 65 and over. Male COVID-19 patients had elevated mortality risk. The Alpha and Delta variant period showed a higher mortality rate for COVID-19 patients than non-COVID-19 patients.

Conclusion: COVID-19 was associated with a higher risk of mortality in OHCA patients.

查看原文本刊更多论文

COVID-19对院外心脏骤停患者自发性循环恢复死亡率的影响：一项回顾性队列研究

背景：本研究旨在比较不同随访期合并和未感染COVID-19的OHCA患者的死亡率，并探讨影响OHCA结局的因素。方法：本研究利用美国TriNetX合作网络的数据。从2020年1月1日至2023年12月31日的记录中共招募了25271名住院OHCA患者。研究人群分为COVID-19阳性组和COVID-19阴性组。根据随访时间的不同，观察两组患者的死亡风险。对性别、年龄、抗病毒药物使用情况、COVID-19病毒变异流行期进行亚组分析。结果：我们的研究包括每组2776例患者（COVID与非COVID）。主要终点是14天和90天随访时的死亡率。与非COVID-19患者相比，COVID-19患者14天死亡率较低（HR 0.82, 95% CI: 0.76-0.88），但90天死亡率较高（HR 1.16, 95% CI: 1.09-1.24）。次要结局包括65岁以下的COVID-19患者死亡率较高，这一趋势在65岁及以上的患者中持续存在。男性COVID-19患者死亡风险较高。Alpha和Delta变异期显示COVID-19患者的死亡率高于非COVID-19患者。结论：COVID-19与OHCA患者较高的死亡风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Trauma Resuscitation & Emergency Medicine EMERGENCY MEDICINE-

CiteScore

6.10

自引率

6.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The primary topics of interest in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine (SJTREM) are the pre-hospital and early in-hospital diagnostic and therapeutic aspects of emergency medicine, trauma, and resuscitation. Contributions focusing on dispatch, major incidents, etiology, pathophysiology, rehabilitation, epidemiology, prevention, education, training, implementation, work environment, as well as ethical and socio-economic aspects may also be assessed for publication.