Endoscopic features differentiating non-Helicobacter pylori Helicobacter-induced gastric mucosa-associated lymphoid tissue lymphoma with a nodular gastritis-like appearance and H. pylori-induced conventional nodular gastritis

IF 4.7 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive Endoscopy Pub Date : 2025-05-09 DOI:10.1111/den.15042

Yuki Kitadai, Hidehiko Takigawa, Daisuke Shimizu, Misa Ariyoshi, Akiyoshi Tsuboi, Hidenori Tanaka, Ken Yamashita, Yuichi Hiyama, Yoshihiro Kishida, Yuji Urabe, Akira Ishikawa, Toshio Kuwai, Shiro Oka

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引用次数: 0

Abstract

Objectives

Conventional nodular gastritis has been known to be caused by Helicobacter pylori infection. Several cases of gastric mucosa-associated lymphoid tissue (MALT) lymphoma with non-H. pylori Helicobacters (NHPH) exhibit endoscopic findings resembling nodular gastritis. Considering the differences in malignancy, distinguishing between these two conditions is crucial. This study aimed to identify the distinguishing endoscopic features of NHPH-induced gastric MALT lymphoma with nodular gastritis-like appearance (NHPHi-MNG) and H.-induced conventional nodular gastritis (HPi-NG).

Methods

Between 2011 and 2022, we analyzed 17 patients with NHPHi-MNG and 50 patients with HPi-NG at Hiroshima University Hospital and evaluated nodule morphology and distribution patterns.

Results

Compared with the HPi-NG group, the NHPHi-MNG group exhibited significantly larger nodules (2.5 vs. 2.0 mm, P < 0.05) with protruded morphology (protruded/superficial, elevated: 14/3 vs. 8/42, P < 0.05), most prominently in the gastric angulus. The variability in nodule size was significantly higher in the NHPHi-MNG group than in the HPi-NG group (0.85 vs. 0.37 mm, P < 0.05), reflecting nodule heterogeneity. The distance from the gastric angulus to the proximal end of the nodular lesions was significantly greater in the NHPHi-MNG group than in the HPi-NG group (4.4 vs. 1.7 cm, P < 0.05). The nodules in the HPi-NG group were smaller, superficial, elevated, and most prominent in the gastric antrum compared with those in the NHPHi-MNG group. They were predominantly distributed in the gastric antrum with a homogeneous morphology.

Conclusion

NHPHi-MNG and HPi-NG can be endoscopically differentiated according to nodule morphology and distribution. Recognizing these distinguishing features is essential for an accurate diagnosis.

Abstract Image

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内镜特征鉴别非幽门螺杆菌诱导的胃粘膜相关淋巴组织淋巴瘤结节性胃炎样外观和幽门螺杆菌诱导的常规结节性胃炎。

目的：已知常规结节性胃炎是由幽门螺杆菌感染引起的。胃粘膜相关淋巴组织（MALT）淋巴瘤伴非h。幽门螺杆菌（NHPH）的内窥镜表现类似结节性胃炎。考虑到恶性肿瘤的不同，区分这两种情况是至关重要的。本研究旨在探讨nhph诱导的胃MALT淋巴瘤结节性胃炎样外观（nhph - mng）与h - h诱导的常规结节性胃炎（HPi-NG）的内镜特征。方法：2011年至2022年，我们分析了广岛大学医院17例nhph - mng患者和50例HPi-NG患者，并评估了结节形态和分布模式。结果：与HPi-NG组相比，nhph - mng组的结节明显增大（2.5 mm vs. 2.0 mm） P。结论：根据结节的形态和分布，nhph - mng和HPi-NG可在内镜下鉴别。认识到这些显著特征对于准确诊断至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Endoscopy 医学-外科

CiteScore

10.10

自引率

15.10%

发文量

291

审稿时长

6-12 weeks

期刊介绍： Digestive Endoscopy (DEN) is the official journal of the Japan Gastroenterological Endoscopy Society, the Asian Pacific Society for Digestive Endoscopy and the World Endoscopy Organization. Digestive Endoscopy serves as a medium for presenting original articles that offer significant contributions to knowledge in the broad field of endoscopy. The Journal also includes Reviews, Original Articles, How I Do It, Case Reports (only of exceptional interest and novelty are accepted), Letters, Techniques and Images, abstracts and news items that may be of interest to endoscopists.