T2D and Osteoporosis Risk: A Mendelian Randomisation Study.

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Jcpsp-Journal of the College of Physicians and Surgeons Pakistan Pub Date : 2025-04-01 DOI:10.29271/jcpsp.2025.04.447

Zhenming Zeng, Zhenzhen Wang, Xiahai Zheng, Tao Jiang, Min Shao, Yong Lian

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引用次数: 0

Abstract

Objective: To investigate the causal effect of Type-II Diabetes (T2D) on osteoporosis (OP) risk using a two-example Mendelian randomisation (MR).

Study design: Descriptive study. Place and Duration of the Study: Third School of Clinical Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China, from February to July 2024.

Methodology: The data of the whole gene association study (GWAS) were gathered from two separate databases and the same East Asia descent, including 433,540 genetic variants in T2D and 212,453 genetic variants in osteoporosis. These genetic variants were used as instrumental variables, subsequently, these variables were analysed by several methods, including inverse variance weighted (IVW)-random effects, MR-Egger regression, and weighted median estimator (WM).

Results: The outcomes indicated that a potential causal association existed between T2D and OP in the primary MR analysis (IVW: Odds ratio (OR) = 1.0934, 95% confidence interval (95% CI): 0.8735-0.9643, p = 0.0007). Meanwhile, the secondary MR also revealed that T2D was causally associated with OP (MR-Egger: OR = 1.1142, 95% CI: 0.9511-0.9966, p = 0.0004, and WME: OR = 1.1422, 95% CI: 0.8611-0.9666, p = 0.0004). The accuracy and robustness of the above results were confirmed using sensitivity tests.

Conclusion: A causal relationship was found between T2D and OP, which also revealed that T2D increased the risk of OP.

Key words: Mendelian randomisation, Type-II diabetes, Osteoporosis, Causal inference.

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T2D和骨质疏松风险：一项孟德尔随机研究。

目的：采用双例孟德尔随机化（MR）研究ii型糖尿病（T2D）与骨质疏松症（OP）风险的因果关系。研究设计：描述性研究。研究地点和时间：广州中医药大学第三临床医学院，中国广州，2024年2月至7月。方法：全基因关联研究（GWAS）的数据来自两个独立的数据库和同一东亚血统，包括T2D的433,540个遗传变异和骨质疏松症的212,453个遗传变异。这些遗传变异被用作工具变量，随后，通过几种方法对这些变量进行分析，包括逆方差加权（IVW）随机效应、MR-Egger回归和加权中位数估计（WM）。结果：初步MR分析结果显示T2D与OP之间存在潜在的因果关系(IVW：优势比（OR) = 1.0934, 95%可信区间（95% CI）： 0.8735-0.9643, p = 0.0007）。同时，二次MR也显示T2D与OP有因果关系（MR- egger: OR = 1.1142, 95% CI: 0.9511-0.9966, p = 0.0004; WME: OR = 1.1422, 95% CI: 0.8611-0.9666, p = 0.0004）。通过敏感性试验验证了上述结果的准确性和稳健性。结论：T2D与OP之间存在因果关系，T2D增加了OP的风险。关键词：孟德尔随机化，ii型糖尿病，骨质疏松症，因果推理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jcpsp-Journal of the College of Physicians and Surgeons Pakistan MEDICINE, GENERAL & INTERNAL-

CiteScore

1.40

自引率

0.00%

发文量

453

审稿时长

3-6 weeks

期刊介绍： Journal of College of Physicians and Surgeons Pakistan (JCPSP), is the prestigious, peer reviewed monthly biomedical journal of the country published regularly since 1991. Established with the primary aim of promotion and dissemination of medical research and contributed by scholars of biomedical sciences from Pakistan and abroad, it carries original research papers, , case reports, review articles, articles on medical education, commentaries, short communication, new technology, editorials and letters to the editor. It covers the core biomedical health science subjects, basic medical sciences and emerging community problems, prepared in accordance with the “Uniform requirements for submission to bio-medical journals” laid down by International Committee of Medical Journals Editors (ICMJE). All publications of JCPSP are peer reviewed by subject specialists from Pakistan and locally and abroad.