Impact of Ursodiol on Number of Cholecystectomies Performed After Bariatric Surgery.

IF 1.1 4区医学 Q3 SURGERY

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques Pub Date : 2025-05-07 DOI:10.1097/SLE.0000000000001354

Romulo Lind, Estela Abich, Rodrigo Neves, Icaro Barreto, Kareem Jawad, Muhammad Ghanem, Muhammad A Jawad, Andre F Teixeira, Graziella Galvao Goncalves

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引用次数: 0

Abstract

Background: The risk of gallstone formation is greater in obese patients; paradoxically, the rapid weight loss after bariatric surgery (BS) is also a great contributor to cholelithiasis and biliary disease. While concomitant cholecystectomy has been used to mitigate this issue, the demand for a less invasive prophylaxis was met by ursodeoxycholic acid (UDCA). This study aims to evaluate the impact of UDCA on the incidence of cholecystectomies after BS.

Methods: This retrospective chart review included all primary and revisional bariatric procedures. Patients were divided into 2 groups based on the postoperative use of daily 600 mg UDCA for 6 months (group 2) or no UDCA use (group 1) to assess its impact on the incidence of cholecystectomy. A subanalysis compared baseline demographics, weight loss performance, and the number of cholecystectomies between groups.

Results: In a cohort of 8433 patients, 5061 were in group 1, and 3372 were in group 2 who received UDCA. The total number of cholecystectomies after BS was 164 (1.9% of the cohort): 146 in group 1 (2.9%) and 18 in group 2 (0.5%) (P<0.00). A subanalysis revealed no significant differences in preoperative weight, body mass index (BMI), and postoperative total body weight loss (TBWL%) between the groups. Nonetheless, incidences of cholecystectomy after biliopancreatic diversion with duodenal switch (BPD-DS), Roux-en-Y Gastric Bypass (RYGB), and sleeve gastrectomy (SG) were greater in group 1, 8% versus 1.4%, 4.4% versus 0.1%, and 1.7% versus 0.4%, respectively (all P<0.05).

Conclusion: UDCA is associated with lower incidence rates of cholecystectomy after BS.

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熊二醇对减肥手术后胆囊切除术次数的影响。

背景：肥胖患者胆结石形成的风险更大；矛盾的是，减肥手术（BS）后的快速体重减轻也是胆石症和胆道疾病的重要因素。虽然合并胆囊切除术已被用于缓解这一问题，但熊去氧胆酸（UDCA）满足了对微创预防的需求。本研究旨在评估UDCA对BS后胆囊切除术发生率的影响。方法：本回顾性图表回顾包括所有原发性和改进性减肥手术。根据术后每日使用600 mg UDCA 6个月（2组）或不使用UDCA（1组）将患者分为2组，以评估其对胆囊切除术发生率的影响。一项亚分析比较了两组之间的基线人口统计学、减肥效果和胆囊切除术次数。结果：在8433例患者中，接受UDCA治疗的组1为5061例，组2为3372例。BS术后胆囊切除术总数为164例（占队列的1.9%）：1组146例（2.9%），2组18例（0.5%）（结论：UDCA与BS术后胆囊切除术发生率较低相关）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 医学-外科

CiteScore

2.00

自引率

10.00%

发文量

103

审稿时长

3-8 weeks

期刊介绍： Surgical Laparoscopy Endoscopy & Percutaneous Techniques is a primary source for peer-reviewed, original articles on the newest techniques and applications in operative laparoscopy and endoscopy. Its Editorial Board includes many of the surgeons who pioneered the use of these revolutionary techniques. The journal provides complete, timely, accurate, practical coverage of laparoscopic and endoscopic techniques and procedures; current clinical and basic science research; preoperative and postoperative patient management; complications in laparoscopic and endoscopic surgery; and new developments in instrumentation and technology.