Transanal endoscopic microsurgery in the treatment of rectal neuroendocrine tumors: a retrospective 10-year single-center experience.

IF 2.1 3区医学 Q2 SURGERY

Langenbeck's Archives of Surgery Pub Date : 2025-04-22 DOI:10.1007/s00423-025-03704-w

Marek Szczepkowski, Piotr Witkowski, Alicja Przywózka-Suwała, Karolina Skonieczna-Żydecka, Teresa Starzyńska, Krzysztof Dąbkowski

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引用次数: 0

Abstract

Purpose: Transanal endoscopic surgery is a recommended full-thickness resection technique for the treatment of rectal neuroendocrine tumors. We aimed to compare the efficacy, safety and follow-up of patients with rectal neuroendocrine tumors treated with transanal endoscopic microsurgery in the primary setting and as salvage therapy after non-radical endoscopic polypectomy.

Methods: A retrospective analysis of a 10-year database of patients treated with transanal endoscopic microsurgery was performed. The procedure-related measures, including duration of the procedure, adverse events, and patient-related measures, including age, gender, tumor size, grading, and length of follow-up, were obtained. We compared the primary TEM group with the salvage group.

Results: In total, 30 patients with rectal neuroendocrine tumors were included in the study; 13 of them received primary treatment and 17 salvage therapy of the scar. Patients receiving primary treatment were significantly older (60.5 vs. 51.7 years). There were no significant differences in patient gender, tumor size and grading, length of follow-up, hospital stay or procedure time. The R0 resection rate was 92.3% in the primary treatment group. Adverse events were mild or managed with endoscopic treatment. Follow-up was slightly but not significantly longer in the primary treatment group and showed no recurrences in both groups of patients.

Conclusions: Transanal endoscopic microsurgery is safe and effective for both primary and salvage treatment of rectal neuroendocrine tumors.

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经肛门内窥镜显微手术治疗直肠神经内分泌肿瘤：回顾性10年单中心经验。

目的：经肛门内镜手术是治疗直肠神经内分泌肿瘤的一种推荐的全层切除技术。我们的目的是比较经肛门内镜显微手术在原发性和非根治性息肉切除术后作为挽救性治疗的直肠神经内分泌肿瘤患者的疗效、安全性和随访情况。方法：回顾性分析10年经肛门内镜显微手术患者的数据库。获得手术相关措施，包括手术持续时间、不良事件和患者相关措施，包括年龄、性别、肿瘤大小、分级和随访时间。我们将TEM初始组与抢救组进行比较。结果：共纳入30例直肠神经内分泌肿瘤患者；初步治疗13例，疤痕补救性治疗17例。接受初级治疗的患者明显更老（60.5岁比51.7岁）。患者性别、肿瘤大小和分级、随访时间、住院时间和手术时间均无显著差异。初次治疗组R0切除率为92.3%。不良事件轻微或通过内窥镜治疗得到控制。初级治疗组随访时间稍长但不明显，两组患者均无复发。结论：经肛门内镜显微手术治疗直肠神经内分泌肿瘤是一种安全有效的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Langenbeck's Archives of Surgery 医学-外科

CiteScore

3.30

自引率

8.70%

发文量

342

审稿时长

4-8 weeks

期刊介绍： Langenbeck''s Archives of Surgery aims to publish the best results in the field of clinical surgery and basic surgical research. The main focus is on providing the highest level of clinical research and clinically relevant basic research. The journal, published exclusively in English, will provide an international discussion forum for the controlled results of clinical surgery. The majority of published contributions will be original articles reporting on clinical data from general and visceral surgery, while endocrine surgery will also be covered. Papers on basic surgical principles from the fields of traumatology, vascular and thoracic surgery are also welcome. Evidence-based medicine is an important criterion for the acceptance of papers.