Cheng Zhong, Li-Hua Wang, Hao-Peng Zhang, Lin Ji, Yu Guo
{"title":"Multiomics: Two-Sample, Bidirectional, Multivariate and Mediated Mendelian Randomization Analysis of Allergic Rhinitis.","authors":"Cheng Zhong, Li-Hua Wang, Hao-Peng Zhang, Lin Ji, Yu Guo","doi":"10.1007/s12070-025-05413-8","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates the potential causal relationships among immune cells, plasma liposomes, and plasma metabolites in allergic rhinitis (AR) using a two-sample bidirectional multivariate and mediated Mendelian Randomization (MR) approach. Genetic data from five GWAS datasets covering traits linked to immune cells, plasma liposomes, plasma metabolites, and AR were used. Instrumental variables were selected based on strict criteria to ensure independence and exclude confounders. The primary MR analysis employed the Inverse Variance Weighted method, supplemented by sensitivity analyses using the Weighted Median and MR-Egger methods. The MR analyses suggest a genetic correlation among immune cells, plasma liposomes, and plasma metabolites, influencing the risk of AR. Findings were robust across various sensitivity analyses, supporting the absence of pleiotropy and outliers. No reverse causality was found, indicating a unidirectional influence. Genetic predispositions to immune cells, plasma liposomes, and plasma metabolites significantly change the risk of developing AR. Further studies are needed to explore these associations in diverse populations and refine the underlying mechanisms.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12070-025-05413-8.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 4","pages":"1823-1830"},"PeriodicalIF":0.6000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985736/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Otolaryngology and Head and Neck Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12070-025-05413-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/17 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigates the potential causal relationships among immune cells, plasma liposomes, and plasma metabolites in allergic rhinitis (AR) using a two-sample bidirectional multivariate and mediated Mendelian Randomization (MR) approach. Genetic data from five GWAS datasets covering traits linked to immune cells, plasma liposomes, plasma metabolites, and AR were used. Instrumental variables were selected based on strict criteria to ensure independence and exclude confounders. The primary MR analysis employed the Inverse Variance Weighted method, supplemented by sensitivity analyses using the Weighted Median and MR-Egger methods. The MR analyses suggest a genetic correlation among immune cells, plasma liposomes, and plasma metabolites, influencing the risk of AR. Findings were robust across various sensitivity analyses, supporting the absence of pleiotropy and outliers. No reverse causality was found, indicating a unidirectional influence. Genetic predispositions to immune cells, plasma liposomes, and plasma metabolites significantly change the risk of developing AR. Further studies are needed to explore these associations in diverse populations and refine the underlying mechanisms.
Supplementary information: The online version contains supplementary material available at 10.1007/s12070-025-05413-8.
期刊介绍：
Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress.
IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc.
The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world.
The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members.
Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
