{"title":"Cardiac arrest due to airway obstruction in Angiotensin-converting enzyme inhibitor-induced angioedema.","authors":"Antoine Ducuing, Eric Deberdt","doi":"10.1016/j.ajem.2025.04.022","DOIUrl":null,"url":null,"abstract":"<p><p>Angiotensin-converting enzyme inhibitor-induced angioedema is a rare but serious side effect of angiotensin-converting enzyme inhibitors (ACEi). It causes bradykinin accumulaztion, leading to the swelling of various tissus, including upper airway. A significant proportion of affected patients require intubation to secure the airway, and in the most severe cases, a tracheostomy. Here, we present the case of a 63-year-old male patient who suffered hypoxic cardiopulmonary arrest due to ACEi-induced angioedema. Due to complete airway obstruction, this patient required an emergency cricothyroidotomy followed by a tracheostomy for effective ventilation. Despite the severity of his condition, the patient made a full recovery. This case highlights the severity ACEi-induced angioedema, the importance of early detection, and the need for emergency airway management in critical cases.</p>","PeriodicalId":55536,"journal":{"name":"American Journal of Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Emergency Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajem.2025.04.022","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"EMERGENCY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Angiotensin-converting enzyme inhibitor-induced angioedema is a rare but serious side effect of angiotensin-converting enzyme inhibitors (ACEi). It causes bradykinin accumulaztion, leading to the swelling of various tissus, including upper airway. A significant proportion of affected patients require intubation to secure the airway, and in the most severe cases, a tracheostomy. Here, we present the case of a 63-year-old male patient who suffered hypoxic cardiopulmonary arrest due to ACEi-induced angioedema. Due to complete airway obstruction, this patient required an emergency cricothyroidotomy followed by a tracheostomy for effective ventilation. Despite the severity of his condition, the patient made a full recovery. This case highlights the severity ACEi-induced angioedema, the importance of early detection, and the need for emergency airway management in critical cases.
期刊介绍:
A distinctive blend of practicality and scholarliness makes the American Journal of Emergency Medicine a key source for information on emergency medical care. Covering all activities concerned with emergency medicine, it is the journal to turn to for information to help increase the ability to understand, recognize and treat emergency conditions. Issues contain clinical articles, case reports, review articles, editorials, international notes, book reviews and more.