The diagnostic significance of miR-20b-5p in schizophrenia and its impact on the symptoms of schizophrenia.

IF 1.4 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2025-06-01 Epub Date: 2025-04-08 DOI:10.1097/YPG.0000000000000393

Jianhui Li, Yao Cheng, Wei Lu

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引用次数: 0

Abstract

Objective: Schizophrenia is a long-term neurological condition that impacts the quality of life of patients. To explore the expression of miR-20b-5p in schizophrenia, to analyze the diagnostic role of miR-20b-5p in schizophrenia, and to demonstrate that miR-20b-5p affects the progression of schizophrenia.

Methods: The expression of miR-20b-5p was detected by real-time quantitative PCR. The diagnostic role of miR-20b-5p in schizophrenia was analyzed by receiver operating characteristic (ROC) curves. A schizophrenic rat model was constructed by injecting MK-801, and anxiety and cognition in schizophrenic rats were evaluated by an open-field test, novel object recognition test, and Morris water maze test.

Results: The expression level of miR-20b-5p was decreased in individuals with schizophrenia, and it could serve as a potential biomarker for the diagnosis of schizophrenia. In addition, miR-20b-5p affected anxiety-like and cognitive behavior in schizophrenic rats.

Conclusion: miR-20b-5p may inhibit the progression of schizophrenia.

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miR-20b-5p在精神分裂症中的诊断意义及其对精神分裂症症状的影响

目的：精神分裂症是一种影响患者生活质量的长期神经系统疾病。探讨miR-20b-5p在精神分裂症中的表达，分析miR-20b-5p在精神分裂症中的诊断作用，证明miR-20b-5p影响精神分裂症的进展。方法：采用实时荧光定量PCR检测miR-20b-5p的表达。采用受试者工作特征（ROC）曲线分析miR-20b-5p对精神分裂症的诊断作用。通过注射MK-801建立精神分裂症大鼠模型，采用开场实验、新物体识别实验和Morris水迷宫实验评价精神分裂症大鼠的焦虑和认知能力。结果：miR-20b-5p在精神分裂症患者中表达水平降低，可作为诊断精神分裂症的潜在生物标志物。此外，miR-20b-5p影响精神分裂症大鼠的焦虑样行为和认知行为。结论：miR-20b-5p可能抑制精神分裂症的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.