Feasibility of pharmacogenetic-guided selection of postoperative analgesics in gynecologic surgery patients: a prospective, randomized, pilot study.

IF 1.7 3区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Glenda Hoffecker, Lakeisha Mulugeta-Gordon, Victoria Wittner, Xingmei Wang, Stefan Gysler, Mary Deagostino-Kelly, Sony Tuteja
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引用次数: 0

Abstract

Objectives: Evaluate the feasibility of implementing a multigene pharmacogenetic (PGx) test and genotype-guided pharmacist recommendations into gynecologic perioperative workflows and fidelity to pharmacist genotype-guided postoperative analgesic recommendations.

Methods: A randomized, prospective, open-label pilot study was conducted in gynecologic patients undergoing abdominal surgery. Participants received multigene PGx testing and were randomized to the PGx-guided group where results were returned to the electronic health record with pharmacist genotype-guided postoperative analgesic recommendations or usual care. Primary outcomes included the proportion of PGx results and pharmacist recommendations completed before surgery, the number of prescriptions in alignment with pharmacist recommendations, and the proportion of analgesics prescribed differing from usual care.

Results: Of the 101 participants analyzed, all were female, 50 ± 14 years old, 49% were Black, 48% were White, 60% were treated by gynecologic oncology, and 76% underwent minimally invasive surgery. PGx results were returned to the genomics results portal a median of 7 (interquartile range: 6-9) business days after ordering the test. A majority (85%) of results were returned before the participant's surgery. Pharmacist genotype-guided analgesic recommendations were completed for 35 (73%) of the 48 participants in the PGx-guided group. And, 32 (91%) of the prescribed nonsteroidal anti-inflammatory drugs and 23 (66%) of the prescribed opioids matched the pharmacist's recommendations. Barriers included missed pharmacist notes when surgery dates were moved and low use of study-specific order set.

Conclusion: PGx test results were available before most surgeries, but the pharmacist recommendations were not always followed. Enhanced implementation strategies will need to be developed in future genotype-guided protocols.

药理学指导下妇科手术患者术后镇痛药选择的可行性:一项前瞻性、随机、试点研究。
目的:评估在妇科围手术期工作流程中实施多基因药物遗传学(PGx)检测和基因型指导的药师推荐的可行性,以及药师基因型指导的术后镇痛推荐的保真度。方法:对接受腹部手术的妇科患者进行一项随机、前瞻性、开放标签的初步研究。参与者接受多基因PGx检测,并随机分配到PGx引导组,结果返回到电子健康记录中,并提供药剂师基因型指导的术后镇痛建议或常规护理。主要结局包括术前完成PGx结果和药师建议的比例,与药师建议一致的处方数量,以及与常规护理不同的镇痛药处方比例。结果:101例患者均为女性,年龄50±14岁,黑人49%,白人48%,60%接受妇科肿瘤治疗,76%接受微创手术。PGx结果在订购检测后中位数为7(四分位数间距:6-9)个工作日返回到基因组学结果门户。大多数(85%)的结果在参与者手术前返回。在pgx引导组的48名参与者中,有35名(73%)完成了药剂师基因型引导的镇痛推荐。32(91%)的处方非甾体类抗炎药和23(66%)的处方阿片类药物符合药剂师的建议。障碍包括当手术日期被移动时遗漏了药剂师的说明,以及研究特定顺序设置的低使用率。结论:PGx检测结果在手术前可获得,但并不总是遵循药师的建议。需要在未来的基因型指导方案中制定加强的实施策略。
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来源期刊
Pharmacogenetics and genomics
Pharmacogenetics and genomics 医学-生物工程与应用微生物
CiteScore
3.20
自引率
3.80%
发文量
47
审稿时长
3 months
期刊介绍: ​​​​Pharmacogenetics and Genomics is devoted to the rapid publication of research papers, brief review articles and short communications on genetic determinants in response to drugs and other chemicals in humans and animals. The Journal brings together papers from the entire spectrum of biomedical research and science, including biochemistry, bioinformatics, clinical pharmacology, clinical pharmacy, epidemiology, genetics, genomics, molecular biology, pharmacology, pharmaceutical sciences, and toxicology. Under a single cover, the Journal provides a forum for all aspects of the genetics and genomics of host response to exogenous chemicals: from the gene to the clinic.
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