The Effect of Midazolam on Remifentanil-Induced Difficulty in Mask Ventilation: A Randomised Study.

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Jcpsp-Journal of the College of Physicians and Surgeons Pakistan Pub Date : 2025-05-01 DOI:10.29271/jcpsp.2025.05.616

Rafet Yarimoglu, Betul Basaran

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引用次数: 0

Abstract

Objective: To explore the impact of midazolam premedication on the difficulty of mask ventilation induced by remifentanil during general anaesthesia induction.

Study design: A prospective, randomised, double-blind study. Place and Duration of the Study: This study was conducted at Karaman Training and Research Hospital, Karaman, Turkiye, from May 2022 to January 2024.

Methodology: This study included 120 patients aged 18-60 years with ASA score I-II scheduled to undergo general anaesthesia for elective surgery. The patients were randomly divided into two groups: Group M and Group C. Patients in Group M received midazolam premedication before induction, while patients in Group C received saline. After the general anaesthesia induction, the level of mask ventilation difficulty for the patients was evaluated using the Warters scale as a primary outcome of the study, in which an independent Sample t-test was used for comparison.

Results: The groups showed a significant difference in Warters scale results distribution (p <0.001). The mean Warters scores were 1.58 (2.03) in Group M and 3.40 (2.26) in Group C.

Conclusion: The study concluded that using midazolam premedication can help prevent difficulties with mask ventilation that may arise with the use of remifentanil during anaesthesia induction. The results also showed that midazolam premedication can facilitate mask ventilation for patients with risk factors for difficult mask ventilation.

Key words: Anaesthesia, General, Airway management, Midazolam, Opioids, Premedication, Remifentanil.

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咪达唑仑对瑞芬太尼引起的面罩通气困难的影响：一项随机研究。

目的：探讨咪达唑仑预用药对瑞芬太尼全麻诱导面罩通气困难的影响。研究设计：前瞻性、随机、双盲研究。研究地点和时间：本研究于2022年5月至2024年1月在土耳其卡拉曼卡拉曼培训和研究医院进行。方法：本研究纳入120例年龄18-60岁，ASA评分为I-II的患者，计划接受全麻择期手术。将患者随机分为M组和C组。M组诱导前给予咪达唑仑预用药，C组给予生理盐水。全麻诱导后，采用Warters量表评估患者口罩通气困难程度，作为研究的主要结局指标，其中采用独立样本t检验进行比较。结果：各组在Warters量表结果分布上存在显著差异(p)。结论：用药前使用咪达唑仑有助于预防麻醉诱导过程中使用瑞芬太尼可能出现的面罩通气困难。结果还表明，咪达唑仑预用药可促进有面罩通气困难危险因素患者的面罩通气。关键词：麻醉，一般，气道管理，咪达唑仑，阿片类药物，用药前，瑞芬太尼。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jcpsp-Journal of the College of Physicians and Surgeons Pakistan MEDICINE, GENERAL & INTERNAL-

CiteScore

1.40

自引率

0.00%

发文量

453

审稿时长

3-6 weeks

期刊介绍： Journal of College of Physicians and Surgeons Pakistan (JCPSP), is the prestigious, peer reviewed monthly biomedical journal of the country published regularly since 1991. Established with the primary aim of promotion and dissemination of medical research and contributed by scholars of biomedical sciences from Pakistan and abroad, it carries original research papers, , case reports, review articles, articles on medical education, commentaries, short communication, new technology, editorials and letters to the editor. It covers the core biomedical health science subjects, basic medical sciences and emerging community problems, prepared in accordance with the “Uniform requirements for submission to bio-medical journals” laid down by International Committee of Medical Journals Editors (ICMJE). All publications of JCPSP are peer reviewed by subject specialists from Pakistan and locally and abroad.