Association between cancer screenings uptake and genetic testing for cancer risk among US adults: findings from HINTS 2017-2020.

IF 1.8 Q4 GENETICS & HEREDITY
Journal of Community Genetics Pub Date : 2025-10-01 Epub Date: 2025-04-30 DOI:10.1007/s12687-025-00797-0
Young-Rock Hong, Ruixuan Wang, Allison Carrier, Luisel Ricks-Santi, Turner Kea, Krupal Patel, Beth A Virnig, Ilyas Sahin, Dejana Braithwaite
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Abstract

Genetic testing for cancer risk is a vital tool for preventive care, yet its association with the uptake of evidence-based cancer screening remains unclear. This study examined the association between cancer-risk genetic testing and cancer screening uptake using data from the Health Information National Trends Survey (2017 and 2020), a nationally representative sample of US adults. We focused on the United States Preventive Services Task Force (USPSTF)-recommended screening tests for colorectal (CRC), breast, and cervical cancers. Multivariable logistic regression models, adjusted for sociodemographic and clinical factors, were used to assess the relationship between cancer screening uptake and cancer-risk genetic testing. The analysis included 6,629 respondents (mean age 48.5 years; 50.7% female; 61.1% non-Hispanic White). Of the respondents, 3.3% had undergone genetic testing for cancer risk. Among eligible populations, screening uptake was 85.2% for Pap tests, 80.8% for mammograms, and 81.3% for CRC. Unadjusted analysis showed a significant association between breast cancer screening and genetic testing (p = 0.005), which lost significance after covariate adjustment. Most respondents who underwent genetic testing received result interpretation assistance from healthcare providers and genetic counselors. Among those who received genetic testing, all respondents who received assistance from genetic counselors were adherent to cancer screening recommendations. Our results suggest that while genetic testing was associated with breast cancer screening in unadjusted analyses, this association was not maintained after adjusting for covariates. No significant associations were found between genetic testing and cervical cancer or CRC screening. Further research using prospective designs is needed to examine the effectiveness of genetic testing in enhancing cancer prevention and screening efforts.

美国成年人癌症筛查与癌症风险基因检测之间的关系:来自hint 2017-2020的研究结果
癌症风险基因检测是预防保健的重要工具,但其与基于证据的癌症筛查的关联尚不清楚。这项研究使用来自健康信息全国趋势调查(2017年和2020年)的数据,研究了癌症风险基因检测与癌症筛查之间的关系,这是一个具有全国代表性的美国成年人样本。我们将重点放在美国预防服务工作组(USPSTF)推荐的结直肠癌、乳腺癌和宫颈癌筛查试验上。采用多变量logistic回归模型,对社会人口学和临床因素进行调整,评估癌症筛查与癌症风险基因检测之间的关系。该分析包括6,629名受访者(平均年龄48.5岁;50.7%的女性;61.1%非西班牙裔白人)。在受访者中,3.3%的人接受过癌症风险基因检测。在符合条件的人群中,巴氏涂片筛查率为85.2%,乳房x光检查为80.8%,CRC筛查率为81.3%。未经调整的分析显示乳腺癌筛查和基因检测之间存在显著相关性(p = 0.005),协变量调整后,这一相关性失去了显著性。大多数接受基因检测的应答者得到了医疗保健提供者和遗传咨询师的结果解释协助。在接受基因检测的人中,所有接受遗传咨询师帮助的受访者都坚持癌症筛查建议。我们的研究结果表明,虽然在未调整的分析中基因检测与乳腺癌筛查相关,但在调整协变量后,这种关联并不维持。没有发现基因检测与子宫颈癌或结直肠癌筛查之间的显著关联。需要使用前瞻性设计进行进一步的研究,以检验基因检测在加强癌症预防和筛查方面的有效性。
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来源期刊
Journal of Community Genetics
Journal of Community Genetics GENETICS & HEREDITY-
CiteScore
3.30
自引率
5.30%
发文量
54
期刊介绍: The Journal of Community Genetics is an international forum for research in the ever-expanding field of community genetics, the art and science of applying medical genetics to human communities for the benefit of their individuals. Community genetics comprises all activities which identify persons at increased genetic risk and has an interest in assessing this risk, in order to enable those at risk to make informed decisions. Community genetics services thus encompass such activities as genetic screening, registration of genetic conditions in the population, routine preconceptional and prenatal genetic consultations, public education on genetic issues, and public debate on related ethical issues. The Journal of Community Genetics has a multidisciplinary scope. It covers medical genetics, epidemiology, genetics in primary care, public health aspects of genetics, and ethical, legal, social and economic issues. Its intention is to serve as a forum for community genetics worldwide, with a focus on low- and middle-income countries. The journal features original research papers, reviews, short communications, program reports, news, and correspondence. Program reports describe illustrative projects in the field of community genetics, e.g., design and progress of an educational program or the protocol and achievement of a gene bank. Case reports describing individual patients are not accepted.
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