{"title":"Treatment of Kasabach-Merritt syndrome in infants' maxillofacial regions with local, accurate administration of urea combined with methylprednisolone.","authors":"Guangzhen Hu, Mengyin Cheng, Jing Huang, Changxian Dong","doi":"10.1007/s10006-025-01393-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Kasabach-Merritt syndrome (KMS) is a rear but dangerous type of hemangioma, which seriously threatens the life safety of KMS patients. The aim of this study is to explore the therapeutic and side effects of local administration of urea combined with methylprednisolone for the treatment of KMS in the maxillofacial region of infants.</p><p><strong>Case presentation: </strong>A total of 14 cases of KMS in infants' maxillofacial region were treated with local injection of 40% urea solution and methylprednisone after the external carotid artery ligation. After 10-36 months of follow-up, 13 out of 14 cases were cured and 1 case was improved. Two cases relapsed and were effectively managed with additional urea injections over 6-10 days. Observed over a 1-2-month period post-treatment, external carotid artery catheterization with urea and methylprednisolone injection is effective for the treatment of maxillofacial KMS in infants.</p><p><strong>Conclusion: </strong>The present study demonstrates that, external carotid artery ligation combined with urea and methylprednisolone can be curative for the treatment KMS in maxillofacial regions of infants, with little trauma and minimal side effect. The combined therapy is recommended for treating severe hemangiomas complicated by Kasabach-Merritt syndrome in maxillofacial region of infants.</p>","PeriodicalId":47251,"journal":{"name":"Oral and Maxillofacial Surgery-Heidelberg","volume":"29 1","pages":"94"},"PeriodicalIF":1.7000,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral and Maxillofacial Surgery-Heidelberg","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s10006-025-01393-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Kasabach-Merritt syndrome (KMS) is a rear but dangerous type of hemangioma, which seriously threatens the life safety of KMS patients. The aim of this study is to explore the therapeutic and side effects of local administration of urea combined with methylprednisolone for the treatment of KMS in the maxillofacial region of infants.
Case presentation: A total of 14 cases of KMS in infants' maxillofacial region were treated with local injection of 40% urea solution and methylprednisone after the external carotid artery ligation. After 10-36 months of follow-up, 13 out of 14 cases were cured and 1 case was improved. Two cases relapsed and were effectively managed with additional urea injections over 6-10 days. Observed over a 1-2-month period post-treatment, external carotid artery catheterization with urea and methylprednisolone injection is effective for the treatment of maxillofacial KMS in infants.
Conclusion: The present study demonstrates that, external carotid artery ligation combined with urea and methylprednisolone can be curative for the treatment KMS in maxillofacial regions of infants, with little trauma and minimal side effect. The combined therapy is recommended for treating severe hemangiomas complicated by Kasabach-Merritt syndrome in maxillofacial region of infants.
期刊介绍：
Oral & Maxillofacial Surgery founded as Mund-, Kiefer- und Gesichtschirurgie is a peer-reviewed online journal. It is designed for clinicians as well as researchers.The quarterly journal offers comprehensive coverage of new techniques, important developments and innovative ideas in oral and maxillofacial surgery and interdisciplinary aspects of cranial, facial and oral diseases and their management. The journal publishes papers of the highest scientific merit and widest possible scope on work in oral and maxillofacial surgery as well as supporting specialties. Practice-oriented articles help improve the methods used in oral and maxillofacial surgery.Every aspect of oral and maxillofacial surgery is fully covered through a range of invited review articles, clinical and research articles, technical notes, abstracts, and case reports. Specific topics are: aesthetic facial surgery, clinical pathology, computer-assisted surgery, congenital and craniofacial deformities, dentoalveolar surgery, head and neck oncology, implant dentistry, oral medicine, orthognathic surgery, reconstructive surgery, skull base surgery, TMJ and trauma.Time-limited reviewing and electronic processing allow to publish articles as fast as possible. Accepted articles are rapidly accessible online.Clinical studies submitted for publication have to include a declaration that they have been approved by an ethical committee according to the World Medical Association Declaration of Helsinki 1964 (last amendment during the 52nd World Medical Association General Assembly, Edinburgh, Scotland, October 2000). Experimental animal studies have to be carried out according to the principles of laboratory animal care (NIH publication No 86-23, revised 1985).
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