Association Between Epicardial Adipose Tissue and Contrast-Induced Acute Kidney Injury in Patients with ST-Segment Elevation Myocardial Infarction.

IF 2.8 3区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Therapeutics and Clinical Risk Management Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI:10.2147/TCRM.S518586

Baohe Zang, Weiwei Hu, Yali Chao, Dengji Wang

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Abstract

Background: Epicardial adipose tissue (EAT) affects the kidneys by secreting various bioactive molecules. Contrast-induced acute kidney injury (CI-AKI) is a common complication after percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) patients. The relationship between EAT and CI-AKI remains unclear. This study aims to explore the relationship between EAT and the incidence of CI-AKI after PCI in STEMI patients.

Methods: Patients diagnosed with STEMI were continuously included, all patients underwent PCI within 12 hours of onset. EAT volume was measured and obtained by chest CT. Logistic regression analysis was used to analyze possible risk factors for CI-AKI. Restricted cubic splines (RCS) were utilized to explore the dose-response relationship involving EAT and CI-AKI.

Results: The incidence of CI-AKI was 8.9% (57/638). Compared with the Non-CI-AKI group, the EAT volume was significantly higher (p<0.005). After adjusting for confounding factors, multivariate regression analysis showed FBG, NT-proBNP, LVEF, and EAT volume were the independent predictors for CI-AKI. RCS analysis indicated a linear dose-response relationship between EAT volume and CI-AKI. The integration of EAT volume could significantly improve ability of the model for CI-AKI (NRI 0.4071, 95% CI 0.231 ~ 0.583, p < 0.001; IDI 0.1356, 95% CI 0.091 ~ 0.180, p < 0.001).

Conclusion: Higher EAT volume was an independent risk factor for CI-AKI in STEMI patients. Integration of EAT volume could significantly improve the risk model for CI-AKI.

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st段抬高型心肌梗死患者心外膜脂肪组织与造影剂诱导急性肾损伤的关系

背景：心外膜脂肪组织（EAT）通过分泌各种生物活性分子影响肾脏。造影剂诱导的急性肾损伤（CI-AKI）是st段抬高型心肌梗死（STEMI）患者经皮冠状动脉介入治疗（PCI）后常见的并发症。EAT与CI-AKI之间的关系尚不清楚。本研究旨在探讨STEMI患者PCI术后EAT与CI-AKI发生率的关系。方法：连续纳入确诊为STEMI的患者，所有患者均在发病12小时内行PCI。通过胸部CT测量并获得EAT体积。采用Logistic回归分析CI-AKI可能的危险因素。采用限制性三次样条（RCS）研究EAT与CI-AKI的剂量-反应关系。结果：CI-AKI发生率为8.9%（57/638）。与非ci - aki组相比，EAT体积显著升高(pp < 0.001；IDI 0.1356, 95% CI 0.091 ~ 0.180, p < 0.001)。结论：较高的EAT容量是STEMI患者CI-AKI的独立危险因素。整合EAT量可以显著改善CI-AKI的风险模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-

CiteScore

5.30

自引率

3.60%

发文量

139

审稿时长

16 weeks

期刊介绍： Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.