D N Andreev, A R Khurmatullina, Y A Kucheryavyy, I V Maev
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引用次数: 0
Abstract
Aim: To systematize data on the prevalence and risk of malnutrition in patients with chronic pancreatitis (CP).
Materials and methods: MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar, Scopus, and the Russian Science Citation Index were searched for studies published between January 1, 1985, and October 23, 2024 (inclusive) based on an analysis of the titles and abstracts of articles in these databases. The study included relevant publications in peer-reviewed periodicals in English or Russian, publications with data on the prevalence of malnutrition in patients with CP and control subjects (if any), studies on adult patients with CP, and publications with detailed descriptive statistics that allow using the data in the meta-analysis.
Results: The final analysis included 13 studies involving 3,812 subjects (3,401 patients with CP and 411 controls). The overall prevalence of malnutrition in patients with CP was 43.43% (95% confidence interval [CI] 32.419-54.780), whereas in controls, it was 10.843% (95% CI 1.360-27.698). When analyzing the association in the overall pool of studies, a significant risk of malnutrition in CP patients compared to controls was shown (relative risk [RR] 3.635, 95% CI 1.409-9.373; p=0.008). The analysis used a random effect model, as there was high heterogeneity between the groups (I2=88.09%, 95% CI 74.76-94.38). A review of studies that used only validated instrumental methods for the diagnosis of malnutrition (criteria of the Global Leadership Initiative on Malnutrition) showed a total prevalence of malnutrition of 38.348% (95% CI 14.975-65.047) in patients with CP and 12.22% (95% CI 5.985-67.238) in control subjects.
Conclusion: This meta-analysis demonstrated that malnutrition is a common complication of CP and occurs in approximately 40% of CP patients. A modern clinician should promptly assess malnutrition markers in a CP patient and correct them using enzyme replacement therapy if detected.
目的：对慢性胰腺炎（CP）患者营养不良的患病率和风险进行系统化分析。材料和方法：检索MEDLINE/PubMed、EMBASE、Cochrane、b谷歌Scholar、Scopus和Russian Science Citation Index，检索1985年1月1日至2024年10月23日（含）发表的研究，并对这些数据库中文章的标题和摘要进行分析。该研究纳入了同行评议的英文或俄文期刊上的相关出版物，包含CP患者和对照受试者（如果有的话）营养不良患病率数据的出版物，关于CP成年患者的研究，以及允许将数据用于meta分析的详细描述性统计出版物。结果：最终分析包括13项研究，涉及3,812名受试者（3,401名CP患者和411名对照组）。CP患者营养不良的总体患病率为43.43%(95%可信区间[CI] 32.419-54.780)，而对照组为10.843% （95% CI 1.360-27.698）。在分析所有研究的相关性时，CP患者与对照组相比存在显著的营养不良风险(相对风险[RR] 3.635, 95% CI 1.409-9.373；p = 0.008)。分析采用随机效应模型，因为组间异质性较高（I2=88.09%, 95% CI 74.76-94.38）。一项仅使用经过验证的工具方法诊断营养不良（全球营养不良领导倡议标准）的研究综述显示，CP患者的营养不良总患病率为38.348% (95% CI 14.975-65.047)，对照组为12.22% （95% CI 5.985-67.238）。结论：该荟萃分析表明，营养不良是CP的常见并发症，约40%的CP患者发生营养不良。现代临床医生应及时评估CP患者的营养不良标志物，并在发现时使用酶替代疗法加以纠正。
期刊介绍：
Терапевтический архив
The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal.
Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases.
The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists.
The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal.
The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory.
The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations.
By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE).
The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.
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