Intra- and inter-scanner CT variability and their impact on diagnostic tasks.

Isabel Montero, Saman Sotoudeh-Paima, Ehsan Abadi, Ehsan Samei
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Abstract

The increased development and production of Computed Tomography (CT) scanner technology has expanded patient access to advanced and affordable medical imaging technologies but has also introduced sources of variability in the clinical imaging landscape, which may influence patient care. This study examines the impact of intra-scanner and inter-scanner variability on image quality and quantitative imaging tasks, with a focus on the detectability index (d') as a measure of patient-specific task performance. We evaluated 813 clinical phantom image sets from the COPDGene study, aggregated by CT scanner make, model, and acquisition and reconstruction protocol. Each phantom image set was assessed for image quality metrics, including the Noise Power Spectrum (NPS) and in-plane Modulation Transfer Function (MTF). The d' index was calculated for 12 hypothetical lesion detection tasks, emulating clinically relevant lung and liver lesions of varying sizes and contrast levels. Qualitatively, analysis showed intra-scanner variability in NPS and MTF curves measured for identical acquisition and reconstruction settings. Inter-scanner comparisons demonstrated variability in d' measurements across different scanner makes and models, of similar acquisition and reconstruction settings. The study showed an intra-scanner variability of up to 13.7% and an inter-scanner variability of up to 19.3% in the d' index. These findings emphasize the need for considering scanner variability in patient-centered care and indicate that CT technology may influence the reliability of imaging tasks. The results of this study further motivate the development of virtual scanner models to better model and mitigate the variability observed in the clinical imaging landscape.

扫描仪内和扫描仪间的CT变异性及其对诊断任务的影响。
计算机断层扫描(CT)扫描仪技术的不断发展和生产扩大了患者获得先进和负担得起的医学成像技术的机会,但也引入了临床成像领域的变变性来源,这可能影响患者的护理。本研究考察了扫描仪内和扫描仪间的可变性对图像质量和定量成像任务的影响,重点关注可检测性指数(d')作为衡量患者特定任务表现的指标。我们评估了来自COPDGene研究的813个临床幻影图像集,这些图像集由CT扫描仪制造、模型、获取和重建方案汇总而成。评估每个幻影图像集的图像质量指标,包括噪声功率谱(NPS)和面内调制传递函数(MTF)。对12个假设的病变检测任务进行d'指数计算,模拟临床相关的不同大小和对比水平的肺和肝病变。定性分析显示,在相同的采集和重建设置下,测量的NPS和MTF曲线的扫描仪内变异性。扫描仪之间的比较表明,在类似的采集和重建设置下,不同扫描仪制造和型号的d'测量值存在差异。研究表明,d'指数的扫描仪内变异性高达13.7%,扫描仪间变异性高达19.3%。这些发现强调了在以患者为中心的护理中考虑扫描仪可变性的必要性,并表明CT技术可能会影响成像任务的可靠性。这项研究的结果进一步推动了虚拟扫描仪模型的发展,以更好地模拟和减轻临床成像领域观察到的可变性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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