"Neuropathological function estimations": a user-friendly module for analyzing neural activity in neurological disorders.

IF 2.4 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY

Bioinformatics advances Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI:10.1093/bioadv/vbaf083

Alessia M Panait, Alex Kim, Rafael Rodriguez-Rojas, Lazaro M Sanchez-Rodriguez, Yasser Iturria-Medina

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引用次数: 0

Abstract

Motivation: This work introduces the Neuropathological Function Estimations software, designed to facilitate the study of neuronal activity alterations in neurological disorders without requiring programming expertise. With its user-friendly interface, researchers can input various data types to generate subject-specific functional brain models and decode neuropathological influences.

Results: The software's capabilities are validated through its application to Alzheimer's disease, providing insights into neuronal excitability and disease mechanisms. This tool has the potential to enhance our understanding of the biological basis of in vivo neural activity and contribute to the development of personalized therapeutic interventions.

Availability and implementation: The latest version of the software and support are freely available for noncommercial users through the Neuroinformatics for Personalized Medicine Lab (NeuroPM Lab) website at McGill University (https://www.neuropm-lab.com/neuropm-box.html). The software is maintained by the NeuroPM team. This publication is linked to version 1.0.

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“神经病理功能估计”：一个用户友好的模块，用于分析神经系统疾病中的神经活动。

动机：这项工作介绍了神经病理功能估计软件，旨在促进神经系统疾病中神经元活动改变的研究，而不需要编程专业知识。通过其用户友好的界面，研究人员可以输入各种数据类型来生成受试者特定的功能脑模型并解码神经病理影响。结果：该软件的功能通过其在阿尔茨海默病中的应用得到验证，为神经元兴奋性和疾病机制提供了见解。这个工具有可能增强我们对体内神经活动的生物学基础的理解，并有助于个性化治疗干预的发展。可用性和实现：非商业用户可以通过麦吉尔大学的个性化医学神经信息学实验室（NeuroPM实验室）网站（https://www.neuropm-lab.com/neuropm-box.html）免费获得最新版本的软件和支持。该软件由NeuroPM团队维护。本出版物链接到1.0版本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioinformatics advances

CiteScore

1.60

自引率

0.00%

发文量