The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling.

IF 3 4区医学 Q2 NEUROSCIENCES

Purinergic Signalling Pub Date : 2025-04-16 DOI:10.1007/s11302-025-10087-6

Andréia Machado Cardoso, André Campos de Lima, Aline Manica, Daniela Zanini, Lucas Macedo Chaves, Samantha Nuncio Prestes, Sedinei Lopes Copatti, Michele Mainardi Pillat, Taís Vidal, Clodoaldo Antônio de Sá

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Abstract

This study investigated the effects of physical exercise (PE) on the modulation of purinergic signaling and inflammatory profiles in sedentary women with type 2 diabetes mellitus (T2DM). Over 16 weeks, participants underwent a combined aerobic and resistance training program. The intervention resulted in reduced extracellular ATP levels and decreased activity of E-NTPDase and ADA enzymes, shifting the inflammatory balance toward an anti-inflammatory profile. A significant increase in anti-inflammatory cytokines (IL-10, IL-4) and a decrease in pro-inflammatory markers (TNF-α, IFN-γ, IL-6) were observed in the T2DM group. Correlations indicated that ATP hydrolysis was inversely related to anti-inflammatory cytokines, supporting the role of PE in modulating purinergic pathways. Additionally, improvements in glycemic control, systolic blood pressure, and functional capacity highlighted the systemic benefits of exercise. These findings emphasize the therapeutic potential of PE in managing T2DM by targeting inflammation and metabolic dysregulation through purinergic modulation. Further studies should explore these mechanisms to optimize exercise-based interventions.

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体育锻炼对2型糖尿病的抗炎作用：嘌呤能信号的作用。

本研究探讨了体育锻炼（PE）对久坐的2型糖尿病（T2DM）女性嘌呤能信号和炎症谱的调节作用。在16周的时间里，参与者进行了有氧和阻力训练的结合。干预导致细胞外ATP水平降低，e - ntpase和ADA酶活性降低，炎症平衡向抗炎方向转变。T2DM组抗炎细胞因子（IL-10、IL-4）显著升高，促炎标志物（TNF-α、IFN-γ、IL-6）显著降低。相关性表明ATP水解与抗炎细胞因子呈负相关，支持PE在调节嘌呤能通路中的作用。此外，血糖控制、收缩压和功能能力的改善突出了运动对全身的益处。这些发现强调了PE通过嘌呤能调节靶向炎症和代谢失调来治疗T2DM的治疗潜力。进一步的研究应该探索这些机制来优化基于运动的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Purinergic Signalling 医学-神经科学

CiteScore

6.60

自引率

17.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.