Association Between the Histological Subtypes, Anatomical Locations, and MAML2 Rearrangement of Head and Neck Mucoepidermoid Carcinoma.

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2025-04-24 DOI:10.1007/s12105-025-01750-w

Yeseul Kim, Joon Seon Song, Seung-Ho Choi, Soon Yuhl Nam, Kyung-Ja Cho

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引用次数: 0

Abstract

Purpose: Mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. MEC harboring MAML2 rearrangement has a favorable prognosis. This study investigated the histologic and locational diversity of head and neck mucoepidermoid carcinoma, clinicopathologic characteristics, and associations with CRTC1/3::MAML2 fusion.

Methods: Patients with head and neck mucoepidermoid carcinoma (n = 128) treated from February 2004 to December 2016 were included. Retrospective analysis encompassed clinical data, pathologic findings, and prognoses, with concurrent performance of fluorescence in situ hybridization to detect MAML2 rearrangement.

Results: The 128 head and neck mucoepidermoid carcinomas comprised 76 parotid gland, 29 oral cavity, 10 submandibular/sublingual, 8 pharynx, 2 lip, 2 sinonasal cavity, and 1 larynx MEC. The parotid gland was the most common site (59%), and the classic subtype was predominant (69%). MAML2 fusion was detected in 84% of analyzed cases and was strongly associated with low-grade tumors (P < 0.001). MAML2-negative cases exhibited higher rates of lymphovascular invasion, nodal metastasis, and poorer outcomes. Tumors in the parotid, submandibular gland, sublingual gland, oral cavity, and oropharynx, showed more frequent MAML2 rearrangement, than nasopharynx, larynx, lip, and paranasal sinus origin (P < 0.001). The classic and Warthin-like subtypes showed higher MAML2 rearrangement than other subtypes (P = 0.001). MAML2 fusion status was a statistically significant predictor of overall survival by univariate (P = 0.039) and multivariate (P = 0.048) analyses.

Conclusion: The presence MAML2 fusion is a favorable prognostic marker in mucoepidermoid carcinoma, with its prevalence varying by location and subtype. Its varying prevalence across locations and subtypes highlights its significant prognostic relevance. These findings underscore the importance of molecular testing and histopathologic evaluation in predicting clinical outcomes.

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头颈部黏液表皮样癌的组织学亚型、解剖位置和MAML2重排之间的关系。

目的：黏液表皮样癌是唾液腺最常见的恶性肿瘤。伴有MAML2重排的MEC预后良好。本研究探讨了头颈部黏液表皮样癌的组织学和部位多样性、临床病理特征以及与CRTC1/3::MAML2融合的关系。方法：选取2004年2月至2016年12月收治的头颈部黏液表皮样癌患者128例。回顾性分析包括临床资料、病理发现和预后，同时采用荧光原位杂交检测MAML2重排。结果：128例头颈部黏液表皮样癌包括腮腺76例，口腔29例，下颌骨/舌下10例，咽部8例，唇部2例，鼻窦2例，喉部MEC 1例。腮腺是最常见的部位（59%），以经典亚型为主（69%）。在84%的分析病例中检测到MAML2融合，并且与低级别肿瘤密切相关(P结论：MAML2融合的存在是粘液表皮样癌的良好预后标志物，其患病率因部位和亚型而异。其不同地区和亚型的患病率突出了其显著的预后相关性。这些发现强调了分子检测和组织病理学评估在预测临床结果中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.