Neuron-Derived Extracellular Vesicles: Emerging Regulators in Central Nervous System Disease Progression.

IF 4.3 2区医学 Q1 NEUROSCIENCES

Molecular Neurobiology Pub Date : 2025-11-01 Epub Date: 2025-05-06 DOI:10.1007/s12035-025-05010-4

Sitong Liu, Aitong Feng, Zhigang Li

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引用次数: 0

Abstract

The diagnosis and exploration of central nervous system (CNS) diseases remain challenging due to the blood-brain barrier (BBB), complex signaling pathways, and heterogeneous clinical manifestations. Neurons, as the core functional units of the CNS, play a pivotal role in CNS disease progression. Extracellular vesicles (EVs), capable of crossing the BBB, facilitate intercellular and cell-extracellular matrix (ECM) communication, making neuron-derived extracellular vesicles (NDEVs) a focal point of research. Recent studies reveal that NDEVs, carrying various bioactive substances, can exert either pathogenic or protective effects in numerous CNS diseases. Additionally, NDEVs show significant potential as biomarkers for CNS diseases. This review summarizes the emerging roles of NDEVs in CNS diseases, including Alzheimer's disease, depression, traumatic brain injury, schizophrenia, ischemic stroke, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. It aims to provide a novel perspective on developing therapeutic and diagnostic strategies for CNS diseases through the study of NDEVs.

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神经元来源的细胞外囊泡：中枢神经系统疾病进展中的新兴调节因子。

由于血脑屏障（BBB）、复杂的信号通路和异质性的临床表现，中枢神经系统（CNS）疾病的诊断和探索仍然具有挑战性。神经元作为中枢神经系统的核心功能单位，在中枢神经系统疾病的进展中起着举足轻重的作用。细胞外囊泡（EVs）能够穿过血脑屏障，促进细胞间和细胞-细胞外基质（ECM）的通信，使神经元源性细胞外囊泡（NDEVs）成为研究的焦点。近年来的研究表明，ndev携带多种生物活性物质，对多种中枢神经系统疾病具有致病或保护作用。此外，ndev显示出作为中枢神经系统疾病生物标志物的巨大潜力。本文综述了ndev在中枢神经系统疾病中的新作用，包括阿尔茨海默病、抑郁症、创伤性脑损伤、精神分裂症、缺血性中风、帕金森病、肌萎缩侧索硬化症和多发性硬化症。目的是通过对ndev的研究，为开发中枢神经系统疾病的治疗和诊断策略提供一个新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.