Butyrate: a key mediator of gut-brain communication in Alzheimer's disease.

IF 3.5 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Metabolic brain disease Pub Date : 2025-04-23 DOI:10.1007/s11011-025-01617-7

Faeze Kachoueiyan, Niosha Yahyavi Kalkhoran, Anousha Yahyavi Kalkhoran, Ashishkumar Kyada, M M Rekha, Kamlesh Chaudhary, Amit Barwal, Fadhil Faez Sead, Kamal Kant Joshi

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Abstract

Alzheimer's disease (AD), a prevalent neurodegenerative disorder, represents a significant global health challenge, characterized by cognitive decline and neuroinflammation. Recent investigations have highlighted the critical role of the gut-brain axis in the pathogenesis of AD, particularly focusing on the influence of short-chain fatty acids (SCFAs), metabolites produced by the gut microbiota through the fermentation of dietary fiber. Among SCFAs, butyrate has emerged as a crucial mediator, positively impacting various pathological processes associated with AD, including epigenetic regulation, neuroinflammation modulation, maintenance of the blood-brain barrier (BBB), enhanced intestinal integrity, regulation of brain metabolism, and interference with amyloid protein formation as well as tau protein hyperphosphorylation. Furthermore, distinctions in butyrate profile and microbial communities have been observed between AD patients and healthy individuals, underscoring the importance of gut microbiota in AD progression. This review summarizes the current understanding of the many functions of butyrate in reducing the consequences of AD and emphasizes the possibility of addressing the gut microbiota as a therapeutic approach to managing AD.

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丁酸盐：阿尔茨海默病肠-脑通讯的关键介质。

阿尔茨海默病（AD）是一种普遍存在的神经退行性疾病，是一项重大的全球健康挑战，其特征是认知能力下降和神经炎症。最近的研究强调了肠-脑轴在AD发病机制中的关键作用，特别是关注短链脂肪酸（SCFAs）的影响，短链脂肪酸是肠道微生物群通过膳食纤维发酵产生的代谢物。在scfa中，丁酸盐已成为一种重要的介质，积极影响与AD相关的各种病理过程，包括表观遗传调节、神经炎症调节、血脑屏障（BBB）的维持、肠道完整性的增强、脑代谢的调节、淀粉样蛋白形成的干扰以及tau蛋白的过度磷酸化。此外，在AD患者和健康个体之间观察到丁酸盐谱和微生物群落的差异，强调了肠道微生物群在AD进展中的重要性。这篇综述总结了目前对丁酸盐在减少AD后果方面的许多功能的理解，并强调了解决肠道微生物群作为治疗AD的治疗方法的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolic brain disease 医学-内分泌学与代谢

CiteScore

5.90

自引率

5.60%

发文量

248

审稿时长

6-12 weeks

期刊介绍： Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on all metabolic brain disease, including both human and animal studies. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to physicians, neuroscientists, internists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of metabolic brain disorders.