Influence of orientation, size and shape of the region of interest in diffusion MRI along perivascular spaces index.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2025-04-11 DOI:10.1007/s10334-025-01248-0

Patricia Ulloa, Justus Christian Rudolf, Janina Kremer, Aileen Schmidt, Peter Schramm

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引用次数: 0

Abstract

Objective: Diffusion-tensor imaging (DTI) and diffusion-weighted imaging (DWI) along perivascular spaces (ALPS) index have been proposed as noninvasive techniques to indirectly evaluate the glymphatic system function. However, these techniques are sensitive to examination parameters, limiting inter-study comparability. The definition of the region of interest (ROI) has been identified as the primary weakness of the ALPS method. Therefore, we aimed to determine which ROI characteristics would best promote consistent ALPS index analysis.

Methods: We examined 13 healthy volunteers using DTI and DWI to calculate the ALPS index, and compared and determined correlations among 11 different ROI configurations, and tested inter-method reliability.

Results: We found significant differences between different ROI configurations in the ALPS index calculation. Considering ROI characteristics and inter-method reliability, a squared ROI is the most suitable. The ICC between ROI configurations showed good-to-excellent inter-method agreement (mean ICC = 0.83). We did not find significant inter-method differences.

Conclusion: It is important to standardize the ROI characteristics for consistent ALPS index calculation.

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沿血管周围空间指数扩散MRI感兴趣区域的方向、大小和形状的影响。

目的：提出沿血管周围间隙（ALPS）指数的弥散张量成像（DTI）和弥散加权成像（DWI）作为间接评价淋巴系统功能的无创技术。然而，这些技术对检查参数敏感，限制了研究间的可比性。感兴趣区域（ROI）的定义被认为是ALPS方法的主要弱点。因此，我们旨在确定哪种ROI特征最能促进ALPS指数分析的一致性。方法：对13名健康志愿者采用DTI和DWI计算ALPS指数，比较确定11种不同ROI配置之间的相关性，并检验方法间的信度。结果：不同ROI配置在ALPS指数计算上存在显著差异。考虑到ROI的特点和方法间的可靠性，一个平方ROI是最合适的。ROI配置之间的ICC显示出良好到优秀的方法间一致性（平均ICC = 0.83）。我们没有发现显著的方法间差异。结论：标准化ROI特征对一致性ALPS指数计算具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.