The association between dietary live microbe intake and risk of chronic kidney disease among US adults: a cross-sectional survey from NHANES (2001-2018).

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-04-15 DOI:10.1080/0886022X.2025.2488236

Xingzi Liu, Yang Shen, Kaiyi Zhu, Meiling Jin, Qianmei Sun

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引用次数: 0

Abstract

Background: Previous studies have suggested that gut dysbacteriosis may promote the onset of chronic kidney disease (CKD). However, the relationship between consumption of live microorganisms and CKD remains unclear. This study aimed to evaluate the association between dietary consumption of live microorganisms and risk of CKD.

Methods: We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2001 to 2018. Dietary intake was assessed through self-reported questionnaires, while CKD diagnosis was based on glomerular filtration rate and albumin-creatinine ratio measurements.

Results: After adjusting for potential confounders, participants with high live microbial intake had a significantly lower risk of CKD compared to those with low intake [odds ratio (OR): 0.79, 95% confidence interval (CI): 0.68-0.91, p = 0.001]. Similarly, those with moderate/high live microbial intake exhibited a reduced CKD risk compared to the low intake group (OR: 0.87, 95% CI: 0.78-0.97, p = 0.009). Subgroup analyses revealed a significant interaction between live microbial intake and CKD risk among participants with less than a high school education, as well as among Mexican Americans and other racial groups (including multiracial) (all P values for interaction < 0.05). A U-shaped dose-response relationship was identified between microbial intake and CKD risk, with significant non-linear associations observed for high consumption levels (P for non-linearity = 0.013).

Conclusions: High dietary intake of live microorganisms is associated with a lower risk of CKD, highlighting the potential role of gut microbiota modulation in CKD prevention.

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美国成年人饮食活微生物摄入量与慢性肾脏疾病风险之间的关系：来自NHANES的横断面调查（2001-2018）。

背景：以往的研究表明，肠道菌群失调可能促进慢性肾脏疾病（CKD）的发生。然而，食用活微生物与慢性肾病之间的关系尚不清楚。本研究旨在评估饮食中活微生物摄入与CKD风险之间的关系。方法：我们使用2001年至2018年国家健康与营养检查调查（NHANES）的数据进行了横断面分析。饮食摄入量通过自我报告的问卷进行评估，而CKD的诊断基于肾小球滤过率和白蛋白-肌酐比值的测量。结果：在调整了潜在的混杂因素后，与摄入低活微生物的参与者相比，摄入高活微生物的参与者患CKD的风险显著降低[优势比（OR）： 0.79, 95%可信区间（CI）： 0.68-0.91, p = 0.001]。同样，与低摄入组相比，摄入中/高活微生物组CKD风险降低（OR: 0.87, 95% CI: 0.78-0.97, p = 0.009）。亚组分析显示，在受教育程度低于高中的参与者以及墨西哥裔美国人和其他种族群体（包括多种族）中，活微生物摄入量与CKD风险之间存在显著的相互作用（相互作用的P值均< 0.05）。微生物摄入量与CKD风险之间呈u形剂量-反应关系，在高摄入水平下观察到显著的非线性关联（非线性P = 0.013）。结论：高饮食摄入活微生物与较低的CKD风险相关，强调了肠道微生物群调节在CKD预防中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.