Diagnostic Potential of Dp-ucMGP as a Biomarker for Early Detection of Diabetic Kidney Disease in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephrology Pub Date : 2025-05-01 DOI:10.1111/nep.70050

Farazul Hoda, Mawrah Arshad, Mohammad Ahmad Khan, Mohammad Anwar Habib, Abul Kalam Najmi

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引用次数: 0

Abstract

Aim: The limited evidence reports the relationship between plasma dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) and Diabetic kidney disease (DKD) in patients with Type 2 Diabetes Mellitus (T2DM). Therefore, the present study aimed to evaluate the diagnostic potential of dp-ucMGP in DKD among T2DM patients.

Method: This cross-sectional study was conducted from December 2023 to January 2025, including 75 T2DM patients. Participants were classified into three groups based on urinary albumin-to-creatinine ratio (UACR): Normoalbuminuria, microalbuminuria, and macroalbuminuria with n = 25 in each group. Pearson correlation analysis was performed to assess the relationship between dp-ucMGP and other biochemical parameters. Receiver Operating Characteristic (ROC) curve analysis was used to evaluate the diagnostic potential of dp-ucMGP for early detection of DKD. A p value < 0.05 was considered statistically significant.

Results: The plasma dp-ucMGP levels were significantly higher in T2DM patients in the macroalbuminuria group, with a mean of 1069.86 ± 417.56 pmol/L, followed by the microalbuminuria (842.72 ± 342.02 pmol/L) and normoalbuminuria (586.38 ± 336.15 pmol/L) groups. Similarly, higher dp-ucMGP levels were observed in patients with DKD severity stage IV (1401.53 ± 401.49 pmol/L). A negative correlation with eGFR (r = -0.807, p < 0.0001) and a positive correlation with age, serum creatinine, UACR, blood urea, uric acid and triglycerides were observed. The area under the curve (AUC) was 0.913 (95% CI: 0.820-0.960; p < 0.0001) for dp-ucMGP.

Conclusion: In conclusion, our findings revealed that plasma dp-ucMGP could be a potential biomarker to predict the early detection of DKD in patients with T2DM.

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Dp-ucMGP作为2型糖尿病患者糖尿病肾病早期检测的生物标志物的诊断潜力：一项横断面研究

目的：有限的证据报道了2型糖尿病（T2DM）患者血浆去磷酸化非羧化基质Gla蛋白（dp-ucMGP）与糖尿病肾病（DKD）之间的关系。因此，本研究旨在评估dp-ucMGP对T2DM患者DKD的诊断潜力。方法：本横断面研究于2023年12月至2025年1月进行，包括75例T2DM患者。参与者根据尿白蛋白与肌酐比值（UACR）分为三组：正常白蛋白尿、微量白蛋白尿和大量白蛋白尿，每组n = 25。采用Pearson相关分析评价dp-ucMGP与其他生化指标的关系。采用受试者工作特征（ROC）曲线分析评价dp-ucMGP对DKD早期检测的诊断潜力。结果：大蛋白尿组T2DM患者血浆dp-ucMGP水平显著升高，平均为1069.86±417.56 pmol/L，其次为微量蛋白尿组（842.72±342.02 pmol/L）和正常蛋白尿组（586.38±336.15 pmol/L）。同样，DKD严重程度IV期患者的dp-ucMGP水平较高（1401.53±401.49 pmol/L）。结论：血浆dp-ucMGP可能是预测T2DM患者早期发现DKD的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephrology 医学-泌尿学与肾脏学

CiteScore

4.50

自引率

4.00%

发文量

128

审稿时长

4-8 weeks

期刊介绍： Nephrology is published eight times per year by the Asian Pacific Society of Nephrology. It has a special emphasis on the needs of Clinical Nephrologists and those in developing countries. The journal publishes reviews and papers of international interest describing original research concerned with clinical and experimental aspects of nephrology.