Investigating Causal Associations Between Circulating Cytokines and Vestibular Disorders Using Mendelian Randomization: Insights from Large-Scale Genome-Wide Association Studies Data in European Populations.
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引用次数: 0
Abstract
The presence of circulating cytokines has a significant impact on the development and progression of vestibular disorders. However, further investigation is needed to determine the direction of causation and causal effects. By applying two-sample Mendelian randomization (MR), we analyzed the potential causal connection between 41 circulating cytokines and vestibular disorders using the integrated data from genome-wide association studies (GWAS). The major analysis utilized for MR was inverse variance weighted (IVW). To examine reverse causation, we conducted reverse MR analysis. In addition, we assessed the robustness of the findings by performing pleiotropy and heterogeneity tests. Our results demonstrated that two circulating cytokines were significantly correlated with vestibular disorders risk. More specifically, vascular endothelial growth factor [IVW, odds ratio (OR) = 0.999, 95% confidence interval (CI) = 0.999-1.000, P = 0.046] and interleukin-7 (IVW, OR = 0.999, 95% CI = 0.998-1.000, P = 0.033) were negatively correlated with vestibular disorders risks, respectively. No evidence was identified to support associations between the remaining 39 circulating cytokines and vestibular disorders. These findings reveal a distinct correlation between circulating cytokines and vestibular diseases, providing a novel perspective and potential biological target for future clinical interventions for vestibular disorders.
循环细胞因子的存在对前庭疾病的发生和进展有重要影响。然而,需要进一步的调查来确定因果关系的方向和因果效应。通过应用双样本孟德尔随机化(MR),我们利用全基因组关联研究(GWAS)的综合数据分析了41种循环细胞因子与前庭疾病之间的潜在因果关系。MR的主要分析方法是逆方差加权(IVW)。为了检验反向因果关系,我们进行了反向磁共振分析。此外,我们通过进行多效性和异质性检验来评估研究结果的稳健性。我们的研究结果表明,两种循环细胞因子与前庭疾病风险显著相关。更具体地说,血管内皮生长因子[IVW,比值比(OR) = 0.999, 95%可信区间(CI) = 0.999-1.000, P = 0.046]和白细胞介素-7 (IVW, OR = 0.999, 95% CI = 0.998-1.000, P = 0.033)分别与前庭功能障碍风险负相关。没有证据支持剩余的39种循环细胞因子与前庭疾病之间的联系。这些发现揭示了循环细胞因子与前庭疾病之间的明显相关性,为未来前庭疾病的临床干预提供了新的视角和潜在的生物学靶点。
期刊介绍:
Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.