Using host and bacterial genetic approaches to define virulence strategies and protective immunity during Mycobacterium tuberculosis infection.

IF 3.7 2区 生物学 Q2 MICROBIOLOGY
mSphere Pub Date : 2025-05-27 Epub Date: 2025-04-22 DOI:10.1128/msphere.00517-24
Andrew J Olive
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引用次数: 0

Abstract

Infections with Mycobacterium tuberculosis (Mtb) resulted in over one million deaths in 2024, the highest number for any infectious disease. With no vaccines that protect against pulmonary tuberculosis (TB) and the challenges associated with antibiotic therapy, there is a critical need to better understand host-Mtb interactions to help curb this major public health problem. Mtb is arguably the most successful human pathogen, and it survives in diverse environments, resulting in heterogeneous disease outcomes in patients. Five years ago, in my commentary in mSphere, I discussed how Mtb virulence strategies that sense, adapt, and evade killing in the host can be uncovered using genetic approaches. Here, I will come full circle to highlight genetic approaches that recently uncovered new mechanisms regulating protective host responses and Mtb survival tactics. The goal is to highlight a genetic framework to probe a range of unexplored Mtb phenotypes, increase our understanding of host-Mtb interactions, and identify new therapeutic targets that may help prevent TB.

利用宿主和细菌遗传方法确定结核分枝杆菌感染期间的毒力策略和保护性免疫。
2024年,感染结核分枝杆菌(Mtb)导致100多万人死亡,是所有传染病中死亡人数最多的。由于没有预防肺结核的疫苗以及抗生素治疗带来的挑战,迫切需要更好地了解宿主-结核分枝杆菌的相互作用,以帮助遏制这一重大公共卫生问题。结核分枝杆菌可以说是最成功的人类病原体,它在不同的环境中生存,导致患者的疾病结局不同。五年前,我在《mSphere》上的评论中讨论了如何利用遗传方法发现在宿主体内感知、适应和逃避杀伤的结核分枝杆菌毒力策略。在这里,我将绕个圈来强调最近发现的调节保护性宿主反应和结核分枝杆菌生存策略的新机制的遗传方法。目标是突出一个遗传框架来探测一系列未被探索的结核分枝杆菌表型,增加我们对宿主-结核分枝杆菌相互作用的理解,并确定可能有助于预防结核的新治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
mSphere
mSphere Immunology and Microbiology-Microbiology
CiteScore
8.50
自引率
2.10%
发文量
192
审稿时长
11 weeks
期刊介绍: mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.
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