Association of MTHFR Gene with Type 2 Diabetes Mellitus: A Case-Control Study and Meta-Analysis.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Public Health Genomics Pub Date : 2025-01-01 Epub Date: 2025-04-21 DOI:10.1159/000545731

Qian Huang, WeiWei Chang, YuanYuan Wang, HeQiao Zhang, JiaMou Zhou, HuiYan Shen, LinSheng Yang, DongMei Zhang, GuiMei Chen

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引用次数: 0

Abstract

Introduction: Multiple studies have shown that genetic polymorphism in the MTHFR gene is associated with susceptibility to type 2 diabetes mellitus (T2DM), but the results remain controversial. This study was divided into two parts. The first part was to explore the relationship between the SNPs of MTHFR gene (C677T and A1298C) and genetic susceptibility to T2DM. Second, a meta-analysis was performed to evaluate the association between C677T gene and T2DM.

Methods: A case-control study was conducted to assess the association of MTHFR polymorphisms with T2DM risk. A meta-analysis including 7 studies was conducted by using Stata 17.0 software.

Results: In case-control study at the C677T (rs1801133), we found that compared with the AA genotype, GG + GA genotype was associated with an increased risk of T2DM (OR = 1.605; 95% CI: 1.229-2.095; p = 0.001); compared with the GG/GA genotype, AA genotype was associated with a decreased risk of T2DM (OR = 0.620; 95% CI: 0.450-0.855; p = 0.004; OR = 0.625; 95% CI: 0.470-0.830; p = 0.001). After adjusting for age, gender, and BMI statistical differences persisted. In case-control study at the A1298C (rs1801131), there was no significant association in all genetic models after adjusting for age, gender, and BMI. In the overall meta-analysis of the C677T gene, significant heterogeneity was detected in the recessive model (I2 = 89.84%, p < 0.01) and allele model (I2 = 88.38%, p < 0.01). Subgroup analysis showed that there was a significant association in the recessive model (I2 = 76.52%, p < 0.01; OR = 2.27, 95% CI: 1.16-4.44) under random-effects models in Asians.

Conclusions: The results suggest that the C677T polymorphism might have ethnicity-dependent effects in T2DM and may be associated with susceptibility to T2DM in Asians.

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MTHFR基因与2型糖尿病的相关性：病例对照研究和荟萃分析

多项研究表明，MTHFR基因的遗传多态性与2型糖尿病（T2DM）的易感性相关，但结果仍存在争议。本研究分为两部分。第一部分探讨MTHFR基因（C677T和A1298C） snp与T2DM遗传易感性的关系。其次，进行荟萃分析以评估C677T基因与T2DM之间的关系。方法：通过病例对照研究评估MTHFR多态性与T2DM风险的关系。采用Stata17.0软件对7项研究进行meta分析。结果：在C677T（rs1801133）的病例对照研究中，我们发现与AA基因型相比，GG + GA基因型与T2DM风险增加相关(OR=1.605；95% ci: 1.229-2.095；P = 0.001);与GG/GA基因型相比，AA基因型与T2DM风险降低相关(OR=0.620；95% ci: 0.450-0.855；P = 0.004;或= 0.625;95% ci: 0.470-0.830；P = 0.001)。在调整了年龄、性别和BMI后，统计差异仍然存在。在A1298C（rs1801131）的病例对照研究中，在调整年龄、性别和BMI后，所有遗传模型均无显著相关性。在C677T基因的整体荟萃分析中，隐性模型中发现了显著的异质性（I2=89.84%）。结论：结果表明，C677T多态性可能在T2DM中具有种族依赖性，并且可能与亚洲人对T2DM的易感性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Public Health Genomics 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ''Public Health Genomics'' is the leading international journal focusing on the timely translation of genome-based knowledge and technologies into public health, health policies, and healthcare as a whole. This peer-reviewed journal is a bimonthly forum featuring original papers, reviews, short communications, and policy statements. It is supplemented by topic-specific issues providing a comprehensive, holistic and ''all-inclusive'' picture of the chosen subject. Multidisciplinary in scope, it combines theoretical and empirical work from a range of disciplines, notably public health, molecular and medical sciences, the humanities and social sciences. In so doing, it also takes into account rapid scientific advances from fields such as systems biology, microbiomics, epigenomics or information and communication technologies as well as the hight potential of ''big data'' for public health.