Role of Intralesional Vitamin D3 in the Treatment of Cutaneous Warts.

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Jcpsp-Journal of the College of Physicians and Surgeons Pakistan Pub Date : 2025-05-01 DOI:10.29271/jcpsp.2025.05.642

Sabahat Shah, Seemab Khan, Noor Us Sabah

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引用次数: 0

Abstract

Objective: To determine the effect of intralesional vitamin D3 injection in the treatment of cutaneous warts.

Study design: Quasi-experimental study. Place and Duration of the Study: Department of Dermatology, P.N.S. Shifa Hospital, Karachi, Pakistan, from May to November 2023.

Methodology: A total of 30 patients with cutaneous warts of various sizes and durations were selected. Vitamin D3 (0.2 ml, 15 mg/ml) was injected to the base of the warts after anaesthetising with lignocaine (0.2 ml, 20 mg/ml). The injections were repeated two weeks apart for a maximum of 4 sessions or until complete clearance, whichever was earlier. A maximum of two warts were treated per session, and patients were followed up for six months after the last injection.

Results: The patients' average age was 32.20 ± 11.9 years, and their average illness duration was 14.3 ± 6.5 months. Out of the 30 patients, 10 (33.4%) were females and 20 (66.6%) were males. Twenty cases (66.6%) showed complete clearance, seven cases (23.3%) showed a moderate response, and three (10%) showed a mild response. The only side effects observed in 17 (56.6%) cases were mild swelling and irritation at the injection site, both of which went away on their own within a few days.

Conclusion: Intralesional vitamin D3 is an effective and affordable treatment option for cutaneous warts.

Key words: Cutaneous warts, Common warts, Efficacy, Intralesional treatment, Vitamin D3.

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皮损内维生素D3治疗皮肤疣的作用。

目的：观察局部注射维生素D3治疗皮肤疣的疗效。研究设计：准实验研究。研究地点和时间：2023年5月至11月，巴基斯坦卡拉奇P.N.S. Shifa医院皮肤科。方法：选取30例不同大小和持续时间的皮肤疣患者。利多卡因（0.2 ml, 20 mg/ml）麻醉后，在疣底注射维生素D3 （0.2 ml, 15 mg/ml）。注射间隔两周，最多重复4次，或直至完全清除，以较早者为准。每次最多治疗两个疣，最后一次注射后对患者进行了六个月的随访。结果：患者平均年龄32.20±11.9岁，平均病程14.3±6.5个月。30例患者中女性10例（33.4%），男性20例（66.6%）。完全缓解20例（66.6%），中度缓解7例（23.3%），轻度缓解3例（10%）。在17例（56.6%）病例中观察到的唯一副作用是注射部位轻度肿胀和刺激，这两种情况在几天内自行消失。结论：局部注射维生素D3是治疗皮肤疣的一种有效且负担得起的方法。关键词：皮肤疣，常见疣，疗效，病灶内治疗，维生素D3

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来源期刊

Jcpsp-Journal of the College of Physicians and Surgeons Pakistan MEDICINE, GENERAL & INTERNAL-

CiteScore

1.40

自引率

0.00%

发文量

453

审稿时长

3-6 weeks

期刊介绍： Journal of College of Physicians and Surgeons Pakistan (JCPSP), is the prestigious, peer reviewed monthly biomedical journal of the country published regularly since 1991. Established with the primary aim of promotion and dissemination of medical research and contributed by scholars of biomedical sciences from Pakistan and abroad, it carries original research papers, , case reports, review articles, articles on medical education, commentaries, short communication, new technology, editorials and letters to the editor. It covers the core biomedical health science subjects, basic medical sciences and emerging community problems, prepared in accordance with the “Uniform requirements for submission to bio-medical journals” laid down by International Committee of Medical Journals Editors (ICMJE). All publications of JCPSP are peer reviewed by subject specialists from Pakistan and locally and abroad.