A Rare Case of Pituicytoma During Pregnancy.

JCEM case reports Pub Date : 2025-04-11 eCollection Date: 2025-05-01 DOI:10.1210/jcemcr/luaf071
Junchen Wu, Hao Tang, Bo Zhang, Shaojian Lin, Zhe Bao Wu
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Abstract

Pituicytomas are rare benign sellar tumors that originate in the neurohypophysis. We report the first case of a pituicytoma during pregnancy, causing headaches and bilateral temporal visual field defects. A 32-year-old woman at 16 weeks of gestation was admitted to our hospital for headaches and progressively worsening visual impairment. Cranial magnetic resonance imaging (MRI) revealed a sellar lesion that was resected via a neuroendoscopic endonasal-transsphenoid approach. Pathology revealed a pituicytoma with positive progesterone receptor expression. After cerebrospinal fluid (CSF) leakage repair and anti-infective therapy, the patient recovered well and finally gave birth to a healthy child. This is the first case of pituicytoma during pregnancy reported. Pregnancy may have a contributing effect on the progression of progesterone receptor-positive pituicytomas. Surgical intervention, when performed with appropriate perioperative management, can effectively alleviate mass effects caused by pituicytomas in pregnant women while maintaining the safety of the fetus.

妊娠期罕见垂体瘤1例。
垂体瘤是一种罕见的良性鞍区肿瘤,起源于神经垂体。我们报告第一例垂体瘤在怀孕期间,引起头痛和双侧颞区视野缺损。一名妊娠16周的32岁妇女因头痛和逐渐恶化的视力障碍入住我院。颅磁共振成像(MRI)显示鞍病变,经神经内窥镜鼻内-蝶窦入路切除。病理显示垂体瘤伴孕激素受体阳性表达。经脑脊液漏修补及抗感染治疗,患者恢复良好,最终生下一名健康儿童。这是报道的第一例妊娠期垂体瘤。妊娠可能对孕激素受体阳性垂体瘤的进展有促进作用。手术干预,在围手术期处理得当的情况下,可有效缓解垂体瘤对孕妇造成的肿块效应,同时保证胎儿的安全。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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