Risk Factors for Postoperative Infections in Severe Traumatic Brain Injury Patients Undergoing Emergency Craniotomy.

IF 2.8 3区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Therapeutics and Clinical Risk Management Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI:10.2147/TCRM.S512780

Zhiyu Zhang, Lin Xu, Sheng Xu

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Abstract

Background and aim: Severe traumatic brain injury (TBI) patients undergoing emergency craniotomy are at high risk of postoperative infections. This study aims to identify the risk factors associated with these infections to improve patient outcomes.

Methods: A retrospective cohort study was conducted, including 312 severe TBI patients who underwent emergency craniotomy at Brain Hospital of Hunan Province between December 2019 and December 2021. Clinical data were collected, and both univariate and multivariate logistic regression analyses were performed to identify risk factors for postoperative infections.

Results: Among the 312 patients, 57 (18.3%) developed postoperative infections. Multivariate analysis identified several significant risk factors, including older age (OR=1.75, 95% CI: 1.23-2.49), prolonged surgery duration (OR=2.01, 95% CI: 1.38-2.92), presence of preoperative infection (OR=2.59, 95% CI: 1.64-4.09), and lower Glasgow Coma Scale (GCS) score on admission (OR=1.82, 95% CI: 1.21-2.74).

Conclusion: Identifying patients at high risk for postoperative infections can help guide preventive measures and improve outcomes in severe TBI patients undergoing emergency craniotomy.

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重型颅脑损伤急诊开颅术后感染的危险因素

背景与目的：重型颅脑损伤（TBI）患者急诊开颅术后感染风险高。本研究旨在确定与这些感染相关的危险因素，以改善患者的预后。方法：采用回顾性队列研究，纳入2019年12月至2021年12月在湖南省脑科医院急诊开颅的312例重型颅脑损伤患者。收集临床资料，并进行单因素和多因素logistic回归分析，以确定术后感染的危险因素。结果：312例患者中57例（18.3%）发生术后感染。多因素分析确定了几个重要的危险因素，包括年龄较大（OR=1.75, 95% CI: 1.23-2.49）、手术时间延长（OR=2.01, 95% CI: 1.38-2.92）、术前感染（OR=2.59, 95% CI: 1.64-4.09）和入院时格拉斯哥昏迷量表评分较低（OR=1.82, 95% CI: 1.21-2.74）。结论：识别术后感染高危患者有助于指导重型颅脑损伤患者急诊开颅手术的预防措施和改善预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-

CiteScore

5.30

自引率

3.60%

发文量

139

审稿时长

16 weeks

期刊介绍： Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.