G R Bicbavova, O M Drapkina, M Livzan, N Lisyutenko, A E Romanyuk
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引用次数: 0
Abstract
Aim: To evaluate the associated effects of dynapenia and overweight in patients with ulcerative colitis (UC).
Materials and methods: Single-center observational cross-sectional case-control study. 80 patients with UC were divided into groups: 14 UC patients with dinapenia and overweight/obesity; UC and dinapenia patients with normal body weight/body weight deficiency (n=12); overweight/obese UC patients (n=24); UC patients with normal body weight/weight deficiency bodies (n=30). The protocol included: the study of nutrition, physical activity, the risk of nutritional insufficiency, measurement of body mass index, blood pressure, dynamometry, duplex scanning of extracranial vessels, determination of the insulin resistance index (HOMA-IR). The assessment of blood composition parameters included studies of blood lipid composition, C-reactive protein, TNF-α, glucose, insulin, C-peptide, leptin, adiponectin, leptin receptors. Zonulin has been studied in feces.
Statistical methods: median (Me), upper and lower quartiles (Q25, Q75); fraction and standard error of the fraction; Mann-Whitney criterion; Kruskal-Wallis criterion; Pearson's χ2. To identify the statistical relationship, Spearman's correlation coefficient was calculated. Statistical indicators are calculated using Statistica 10.01.1011.
Results: Dinapenia in combination with obesity/overweight is observed in 17.5% of patients with UC, most of them patients with low physical activity. Dinapenic obesity is associated with metainflammation and increased permeability of the epithelial barrier, as evidenced by significantly higher rates of C-reactive protein, TNF-α, HOMA-IR and fecal zonulin. In patients with dinapenia in combination with overweight/obesity, higher leptin levels were determined, and the leptin receptors level was lower than in participants of other groups.
Conclusion: The mechanisms of dinapenia in overweight/obese UC patients include a synergistic effect of inflammation, insulin resistance and increased epithelial permeability.
期刊介绍:
Терапевтический архив
The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal.
Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases.
The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists.
The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal.
The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory.
The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations.
By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE).
The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.