Breakpoint-chiasma interference in pericentric inversion heterokaryotypes.

IF 3.3 3区生物学 Q2 GENETICS & HEREDITY

Genetics Pub Date : 2025-06-04 DOI:10.1093/genetics/iyaf070

Øystein Kapperud

引用次数: 0

Abstract

Heterozygous inversion breakpoints inhibit the formation of chiasmata in their vicinity, and it has been suggested that they do so through the same mechanism that also causes interference between chiasmata. In this paper, I therefore extend my earlier model of chiasma interference to account for interference between breakpoints and chiasmata in pericentric inversion heterokaryotypes. Using this model to analyze recombination and sterility datasets for Drosophila melanogaster, I find support for the hypothesis that inversion breakpoints interfere with chiasmata in the same way and to the same degree that other chiasmata do. I also find that breakpoints, like chiasmata, appear to show negative interference in the pericentromeric region, and positive interference elsewhere. I discuss the implications of these findings in light of the recent HEI10 coarsening interference hypothesis, and conclude with some remarks about the evolutionary origin of chiasma interference.

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中心外反转异核型的断点交叉干扰。

杂合反转断点抑制其附近交叉的形成，有人认为它们是通过同样的机制抑制交叉的形成，也会导致交叉之间的干扰。因此，在本文中，我扩展了我早期的交叉干扰模型，以解释在中心外反转异核型中断点和交叉之间的干扰。使用该模型分析果蝇的重组和不育数据集，我发现反转断点以与其他交叉相同的方式和程度干扰交叉的假设得到了支持。我还发现断点，如交叉，似乎在中心点周围区域显示负干扰，而在其他地方显示正干扰。根据最近的he10粗化干涉假说，我讨论了这些发现的意义，并对交叉干涉的演化起源作了一些评论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genetics GENETICS & HEREDITY-

CiteScore

6.90

自引率

6.10%

发文量

177

审稿时长

1.5 months

期刊介绍： GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work. While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor''s journal. The editors make decisions quickly – in around 30 days – without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists. GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook (coming spring 2016). For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we''ve published thematic collections, including Genomic Selection, Multiparental Populations, Mouse Collaborative Cross, and the Genetics of Sex.