Glycosylation as an intricate post-translational modification process takes part in glycoproteins related immunity.

IF 8.2 2区生物学 Q1 CELL BIOLOGY

Cell Communication and Signaling Pub Date : 2025-05-05 DOI:10.1186/s12964-025-02216-w

Meng Tian, Xiaoyu Li, Liuchunyang Yu, JinXiu Qian, XiuYun Bai, Jue Yang, RongJun Deng, Cheng Lu, Hongyan Zhao, Yuanyan Liu

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Abstract

Protein glycosylation, the most ubiquitous and diverse type of post-translational modification in eukaryotic cells, proteins are input into endoplasmic reticulum and Golgi apparatus for sorting and modification with intricate quality control, are then output for diverse functional glycoproteins that are utilized by cells to precisely regulate various biological processes. In order to maintain the precise spatial structure of glycoprotein, misfolded and unfolded glycoproteins are recognized, segregated and degraded to ensure the fidelity of protein folding and maturation. This review enumerates the role of five immune-related glycoproteins and reveals the relevance of glycosylation to their antigen presentation, immune effector function, immune recognition, receptor binding and activation, and cell adhesion and migration. With the knowledgement of glycoproteins in immune responses and etiologies, we propose several relevant therapeutic strategies on targeting glycosylation process for immunotherapy.

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糖基化是一个复杂的翻译后修饰过程，参与糖蛋白相关免疫。

蛋白质糖基化是真核细胞中最普遍和最多样化的翻译后修饰，蛋白质被输入内质网和高尔基体进行分类和修饰，并进行复杂的质量控制，然后输出各种功能糖蛋白，这些糖蛋白被细胞用来精确调节各种生物过程。为了保持糖蛋白精确的空间结构，对错误折叠和未折叠的糖蛋白进行识别、分离和降解，以保证蛋白质折叠和成熟的保真度。本文综述了五种免疫相关糖蛋白的作用，并揭示了糖基化与其抗原呈递、免疫效应功能、免疫识别、受体结合和激活以及细胞粘附和迁移的相关性。根据糖蛋白在免疫应答和病因学方面的知识，我们提出了针对糖基化过程进行免疫治疗的几种相关治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Communication and Signaling CELL BIOLOGY-

CiteScore

11.00

自引率

0.00%

发文量

180

期刊介绍： Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.