Complementarity and integration of animal and in vitro non-animal pre-clinical model systems- an Australian perspective.

IF 2.7 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Mammalian Genome Pub Date : 2025-05-06 DOI:10.1007/s00335-025-10132-0

Ruth M Arkell, Ernst J Wolvetang, Twishi Gulati, James E Hennessy, Adam P Hill, Thierry Jardé, Andrew J Kueh, Paul Q Thomas, Louise N Winteringham, Michael S Dobbie

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Abstract

Recent advances in the development of pre-clinical models based on non-animal technologies (NATs) have stimulated expectations that the use of animals in research may soon be phased out. The true value of innovations in NATs and their applications lies, however, in enabling an expanded and integrated portfolio of complementary animal and non-animal model systems to improve the accuracy and efficiency of pre-clinical research and therapeutic development. The term NATs covers a range of techniques spanning in silico, cell free, organ-on-chip as well as in vitro techniques including three-dimensional cell culture models termed organoids. Of these, in vitro systems are currently the most broadly used in biomedicine laboratories and are the first NATs for which Australia has invested in nationwide support. The focus of this commentary is the importance of understanding the strengths and limitations of in vitro and animal models such that an integrated portfolio of complementary genetic models continues to evolve to best support pre-clinical research and therapeutic development pipelines.

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动物和体外非动物临床前模型系统的互补性和整合-澳大利亚的观点。

基于非动物技术（NATs）的临床前模型开发的最新进展刺激了人们的期望，即在研究中使用动物可能很快就会被淘汰。然而，NATs创新及其应用的真正价值在于能够扩大和整合互补的动物和非动物模型系统组合，以提高临床前研究和治疗开发的准确性和效率。术语NATs涵盖了一系列技术，包括硅技术、无细胞技术、芯片上器官技术以及体外技术，包括被称为类器官的三维细胞培养模型。其中，体外系统目前是生物医学实验室中使用最广泛的，也是澳大利亚在全国范围内投资支持的第一个体外系统。本评论的重点是了解体外和动物模型的优势和局限性的重要性，以便互补的遗传模型的综合组合继续发展，以最好地支持临床前研究和治疗开发管道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mammalian Genome 生物-生化与分子生物学

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Mammalian Genome focuses on the experimental, theoretical and technical aspects of genetics, genomics, epigenetics and systems biology in mouse, human and other mammalian species, with an emphasis on the relationship between genotype and phenotype, elucidation of biological and disease pathways as well as experimental aspects of interventions, therapeutics, and precision medicine. The journal aims to publish high quality original papers that present novel findings in all areas of mammalian genetic research as well as review articles on areas of topical interest. The journal will also feature commentaries and editorials to inform readers of breakthrough discoveries as well as issues of research standards, policies and ethics.