Comparing the Effects of Glucose-Fructose versus Glucose on the Oxidation Rate: A Systematic Review and Meta-Analysis.

IF 1.4 4区医学 Q3 Medicine

Iranian Journal of Public Health Pub Date : 2025-04-01 DOI:10.18502/ijph.v54i4.18411

Zahra Gohari Dezfuli, Minoo Hasan Rashedi, Fatemeh Naeini, Sakineh Shab-Bidar, Mohammadhossein Pourgharib-Shahi, Xueying Zhang, Elaheh Dehghani, Kurosh Djafarian

{"title":"Comparing the Effects of Glucose-Fructose versus Glucose on the Oxidation Rate: A Systematic Review and Meta-Analysis.","authors":"Zahra Gohari Dezfuli, Minoo Hasan Rashedi, Fatemeh Naeini, Sakineh Shab-Bidar, Mohammadhossein Pourgharib-Shahi, Xueying Zhang, Elaheh Dehghani, Kurosh Djafarian","doi":"10.18502/ijph.v54i4.18411","DOIUrl":null,"url":null,"abstract":"Background: Numerous studies have aimed to compare the effects of glucose (Glu) consumption with those of glucose-fructose (Glu-Fru) consumption on oxidation rates during exercise. However, divergent outcomes have surfaced due to variations in exercise protocols and concurrent substance ingestion, leading to a lack of consensus. This systematic review and meta-analysis investigated the comparative effects of Glu and Glu-Fru on total carbohydrate oxidation, endogenous carbohydrate oxidation, exogenous carbohydrate oxidation, and total fat oxidation rates during exercise.Methods: A systematic search of PubMed, Scopus, and Web of Science databases up to February 2023. The search yielded 14 randomized controlled trials involving 125 endurance athletes.Results: The meta-analyses revealed that Glu supplementation significantly increased total carbohydrate oxidation (WMD: 0.21 g/min) compared to Glu-Fru. Endogenous carbohydrate oxidation significantly increased with Glu (WMD: -0.12), while Glu-Fru led to increased exogenous carbohydrate oxidation (WMD: 0.27 g/min). Total fat oxidation decreased with Glu-Fru (WMD: -0.06 g/min).Conclusion: By investigating athletic nutrition complexities, our findings shed light on metabolic responses to Glu-Fru versus Glu supplementation. Tailoring hydration strategies, athletes should select an optimal Glu-Fru to Glu ratio for maximal oxidation and enhanced performance. Future research could explore dose-response relationships for optimal metabolic benefits during exercise.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"54 4","pages":"723-738"},"PeriodicalIF":1.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045866/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18502/ijph.v54i4.18411","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Numerous studies have aimed to compare the effects of glucose (Glu) consumption with those of glucose-fructose (Glu-Fru) consumption on oxidation rates during exercise. However, divergent outcomes have surfaced due to variations in exercise protocols and concurrent substance ingestion, leading to a lack of consensus. This systematic review and meta-analysis investigated the comparative effects of Glu and Glu-Fru on total carbohydrate oxidation, endogenous carbohydrate oxidation, exogenous carbohydrate oxidation, and total fat oxidation rates during exercise.

Methods: A systematic search of PubMed, Scopus, and Web of Science databases up to February 2023. The search yielded 14 randomized controlled trials involving 125 endurance athletes.

Results: The meta-analyses revealed that Glu supplementation significantly increased total carbohydrate oxidation (WMD: 0.21 g/min) compared to Glu-Fru. Endogenous carbohydrate oxidation significantly increased with Glu (WMD: -0.12), while Glu-Fru led to increased exogenous carbohydrate oxidation (WMD: 0.27 g/min). Total fat oxidation decreased with Glu-Fru (WMD: -0.06 g/min).

Conclusion: By investigating athletic nutrition complexities, our findings shed light on metabolic responses to Glu-Fru versus Glu supplementation. Tailoring hydration strategies, athletes should select an optimal Glu-Fru to Glu ratio for maximal oxidation and enhanced performance. Future research could explore dose-response relationships for optimal metabolic benefits during exercise.

查看原文本刊更多论文

比较葡萄糖-果糖和葡萄糖对氧化速率的影响：一项系统综述和荟萃分析。

背景：许多研究旨在比较葡萄糖（Glu）消耗和葡萄糖-果糖（Glu- fru）消耗对运动中氧化率的影响。然而，由于运动方案的变化和同时摄入的物质，不同的结果已经浮出水面，导致缺乏共识。本系统综述和荟萃分析研究了Glu和Glu- fru在运动过程中对总碳水化合物氧化、内源性碳水化合物氧化、外源性碳水化合物氧化和总脂肪氧化率的比较影响。方法：系统检索截至2023年2月的PubMed、Scopus和Web of Science数据库。这项研究产生了14项随机对照试验，涉及125名耐力运动员。结果：荟萃分析显示，与添加Glu- fru相比，补充Glu显著增加了总碳水化合物氧化（WMD: 0.21 g/min）。内源性碳水化合物氧化显著增加（WMD: -0.12），而Glu- fru导致外源性碳水化合物氧化增加（WMD: 0.27 g/min）。总脂肪氧化随Glu-Fru降低（WMD: -0.06 g/min）。结论：通过研究运动营养的复杂性，我们的发现揭示了对谷氨酸- fru和谷氨酸补充的代谢反应。定制水合策略，运动员应该选择最佳的Glu- fru到Glu的比例，以最大限度地氧化和提高性能。未来的研究可以探索运动中最佳代谢益处的剂量-反应关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Iranian Journal of Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.20

自引率

7.10%

发文量

审稿时长

2 months

期刊介绍： Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.