Influences of variations of the amount of compressed material on compressibility, tabletability and compactability

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Journal of pharmaceutical sciences Pub Date : 2025-05-10 DOI:10.1016/j.xphs.2025.103831

Anh Tuan Tran, Stefan Klinken-Uth

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引用次数: 0

Abstract

Compression analysis is essential for the investigation of materials and processes in the manufacturing of pharmaceutical tablets. In the past, the influence of various process parameters on compression analysis has been investigated. The strength of these influences can significantly depend on the properties of the compressed material. One example is the effect of tablet compression speed on tabletability. The impact of tablet geometry has also been studied. However, what is still missing in the literature is the investigation of the influence of the quantity of the compressed material. This publication provides a starting point for understanding the effect of material quantity in compression analysis. In addition to the material quantity, two different tablet diameters were also investigated. The study demonstrates that the extent to which material quantity has an influence on compression analysis highly depends on the material properties. It clearly shows that the tabletability and even the compactability of materials can vary significantly depending on the amount of material compressed.

查看原文本刊更多论文

压缩量的变化对可压缩性、压实性和压实性的影响。

压缩分析对于药品片剂生产过程中材料和工艺的研究是必不可少的。过去，研究了各种工艺参数对压缩分析的影响。这些影响的强度很大程度上取决于被压缩材料的特性。一个例子是片剂压缩速度对可制表性的影响。还研究了片剂几何形状的影响。然而，文献中仍然缺少的是对压缩材料数量影响的调查。该出版物为理解材料数量在压缩分析中的影响提供了一个起点。除用量外，还考察了两种不同片剂直径。研究表明，材料用量对压缩分析的影响程度在很大程度上取决于材料的性能。它清楚地表明，材料的表性甚至压实性可以根据压缩材料的量而显着变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pharmaceutical sciences 医学-化学综合

CiteScore

7.30

自引率

13.20%

发文量

367

审稿时长

33 days

期刊介绍： The Journal of Pharmaceutical Sciences will publish original research papers, original research notes, invited topical reviews (including Minireviews), and editorial commentary and news. The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals, including crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology, and targeted drug delivery.