Role and Relationship Between Homocysteine and H2S in Ischemic Stroke.

IF 4.3 2区 医学 Q1 NEUROSCIENCES
Molecular Neurobiology Pub Date : 2025-11-01 Epub Date: 2025-05-06 DOI:10.1007/s12035-025-04968-5
Weizhuo Lu, Jiyue Wen
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引用次数: 0

Abstract

Homocysteine (Hcy), a sulfur-containing amino acid, is an important intermediate product of methionine metabolism. Hcy can be either metabolized to cysteine, a precursor for glutathione synthesis and hydrogen sulfide (H2S) production, or regenerated back to methionine. Besides, the Hcy metabolism is central to supply methyl groups, which are essential for DNA methylation. In the transsulfuration pathway of Hcy metabolism, Hcy is metabolized to form cysteine and H2S by catalytic enzymes, containing cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE). Hcy metabolism-related enzymes and coenzymes, such as vitamin B6, vitamin B12, and folic acid, are closely related to hyperhomocysteinemia (HHcy), which is frequently accompanied by reduced H2S content. An accumulating study has revealed that HHcy is a risk factor for ischemic stroke, while H2S, served as a gaseous mediator at the physiological level, has protective effects against ischemic stroke. This review outlined the literature data from recent research related to Hcy metabolism and H2S production and described the roles and relationship among Hcy metabolism and H2S in ischemic stroke.

同型半胱氨酸和H2S在缺血性脑卒中中的作用及关系
同型半胱氨酸(Hcy)是一种含硫氨基酸,是蛋氨酸代谢的重要中间产物。Hcy可以代谢为半胱氨酸,半胱氨酸是合成谷胱甘肽和硫化氢(H2S)的前体,也可以再生为蛋氨酸。此外,Hcy代谢是提供甲基的核心,甲基是DNA甲基化所必需的。在Hcy代谢的转硫途径中,Hcy通过含有半胱硫氨酸-β-合成酶(CBS)和半胱硫氨酸-γ-裂解酶(CSE)的催化酶代谢形成半胱氨酸和H2S。Hcy代谢相关酶和辅酶,如维生素B6、维生素B12、叶酸等与高同型半胱氨酸血症(HHcy)密切相关,常伴有H2S含量降低。越来越多的研究表明,HHcy是缺血性脑卒中的危险因素,而H2S在生理水平上作为气态介质,对缺血性脑卒中具有保护作用。本文综述了近年来Hcy代谢和H2S产生的相关研究文献资料,阐述了Hcy代谢和H2S在缺血性脑卒中中的作用和关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Neurobiology
Molecular Neurobiology 医学-神经科学
CiteScore
9.00
自引率
2.00%
发文量
480
审稿时长
1 months
期刊介绍: Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.
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