Ruixue Cai, Jianqian Chao, Chenlu Gao, Lei Gao, Kun Hu, Peng Li
{"title":"Association Between Sleep Duration and Cognitive Frailty in Older Chinese Adults: Prospective Cohort Study.","authors":"Ruixue Cai, Jianqian Chao, Chenlu Gao, Lei Gao, Kun Hu, Peng Li","doi":"10.2196/65183","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Disturbed sleep patterns are common among older adults and may contribute to cognitive and physical declines. However, evidence for the relationship between sleep duration and cognitive frailty, a concept combining physical frailty and cognitive impairment in older adults, is lacking.</p><p><strong>Objective: </strong>This study aimed to examine the associations of sleep duration and its changes with cognitive frailty.</p><p><strong>Methods: </strong>We analyzed data from the 2008-2018 waves of the Chinese Longitudinal Healthy Longevity Survey. Cognitive frailty was rendered based on the modified Fried frailty phenotype and Mini-Mental State Examination. Sleep duration was categorized as short (<6 h), moderate (6-9 h), and long (>9 h). We examined the association of sleep duration with cognitive frailty status at baseline using logistic regressions and with the future incidence of cognitive frailty using Cox proportional hazards models. Restricted cubic splines were used to explore potential nonlinear associations.</p><p><strong>Results: </strong>Among 11,303 participants, 1298 (11.5%) had cognitive frailty at baseline. Compared to participants who had moderate sleep duration, the odds of having cognitive frailty were higher in those with long sleep duration (odds ratio 1.71, 95% CI 1.48-1.97; P<.001). A J-shaped association between sleep duration and cognitive frailty was also observed (P<.001). Additionally, during a mean follow-up of 6.7 (SD 2.6) years among 5201 participants who were not cognitively frail at baseline, 521 (10%) participants developed cognitive frailty. A higher risk of cognitive frailty was observed in participants with long sleep duration (hazard ratio 1.32, 95% CI 1.07-1.62; P=.008).</p><p><strong>Conclusions: </strong>Long sleep duration was associated with cognitive frailly in older Chinese adults. These findings provide insights into the relationship between sleep duration and cognitive frailty, with potential implications for public health policies and clinical practice.</p>","PeriodicalId":36245,"journal":{"name":"JMIR Aging","volume":"8 ","pages":"e65183"},"PeriodicalIF":5.0000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043274/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JMIR Aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2196/65183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Disturbed sleep patterns are common among older adults and may contribute to cognitive and physical declines. However, evidence for the relationship between sleep duration and cognitive frailty, a concept combining physical frailty and cognitive impairment in older adults, is lacking.
Objective: This study aimed to examine the associations of sleep duration and its changes with cognitive frailty.
Methods: We analyzed data from the 2008-2018 waves of the Chinese Longitudinal Healthy Longevity Survey. Cognitive frailty was rendered based on the modified Fried frailty phenotype and Mini-Mental State Examination. Sleep duration was categorized as short (<6 h), moderate (6-9 h), and long (>9 h). We examined the association of sleep duration with cognitive frailty status at baseline using logistic regressions and with the future incidence of cognitive frailty using Cox proportional hazards models. Restricted cubic splines were used to explore potential nonlinear associations.
Results: Among 11,303 participants, 1298 (11.5%) had cognitive frailty at baseline. Compared to participants who had moderate sleep duration, the odds of having cognitive frailty were higher in those with long sleep duration (odds ratio 1.71, 95% CI 1.48-1.97; P<.001). A J-shaped association between sleep duration and cognitive frailty was also observed (P<.001). Additionally, during a mean follow-up of 6.7 (SD 2.6) years among 5201 participants who were not cognitively frail at baseline, 521 (10%) participants developed cognitive frailty. A higher risk of cognitive frailty was observed in participants with long sleep duration (hazard ratio 1.32, 95% CI 1.07-1.62; P=.008).
Conclusions: Long sleep duration was associated with cognitive frailly in older Chinese adults. These findings provide insights into the relationship between sleep duration and cognitive frailty, with potential implications for public health policies and clinical practice.
背景：睡眠模式紊乱在老年人中很常见，可能导致认知和身体衰退。然而，缺乏睡眠时间与认知衰弱之间关系的证据，认知衰弱是一个结合老年人身体虚弱和认知障碍的概念。目的：本研究旨在探讨睡眠时间及其变化与认知衰弱的关系。方法：我们分析了2008-2018年中国纵向健康寿命调查的数据。认知脆弱是基于改良的Fried脆弱表型和迷你精神状态检查。睡眠时间为短（9小时）。我们使用逻辑回归检验了睡眠时间与基线认知衰弱状态的关系，并使用Cox比例风险模型检验了睡眠时间与未来认知衰弱发生率的关系。限制三次样条用于探索潜在的非线性关联。结果：在11,303名参与者中，1298名（11.5%）在基线时存在认知衰弱。与睡眠时间适中的参与者相比，睡眠时间较长的参与者出现认知衰弱的几率更高(优势比1.71,95% CI 1.48-1.97；结论：中国老年人睡眠时间过长与认知衰弱有关。这些发现为睡眠时间与认知衰弱之间的关系提供了见解，对公共卫生政策和临床实践具有潜在的影响。
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
