{"title":"The Emerging Role of Adropin in Neurological Health: A Systematic Review.","authors":"Rooban Sivakumar, Arul Senghor Kadalangudi Aravaanan, Vinodhini Vellore Mohanakrishnan, Janardhanan Kumar","doi":"10.18502/ijph.v54i4.18407","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Adropin, a peptide hormone has role in various various physiological processes, including metabolic regulation and cardiovascular health. This systematic review aimed to synthesize findings from observational studies on the involvement of adropin in neurological disorders and cognitive performance.</p><p><strong>Methods: </strong>An extensive literature search was conducted across PubMed, Scopus, Web of Science, Embase, CORE, and Google Scholar using terms such as \"adropin,\" \"Neurological Disorders,\" \"cognitive function,\" \"Alzheimer's disease,\" \"Parkinson's disease,\" \"cognition,\" and \"brain function.\" Studies published from 2020 to 2024 were selected and reviewed. The search and selection process adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Out of 127 screened articles, 5 met the inclusion criteria for this review.</p><p><strong>Results: </strong>The combined research findings suggest a consistent link between decreased adropin levels and a range of neurological disorders and cognitive impairments. In particular, reduced adropin levels were seen in individuals with dementia, cognitive impairment, bipolar disorder, Parkinson's disease, and multiple sclerosis. These findings highlight adropin's potential role in modulating neurological health and cognitive function.</p><p><strong>Conclusion: </strong>This systematic review underscores the importance of adropin in neurological health and its potential as a therapeutic agent. Based on the observed connections, adropin might serve as a new focus for treating neurological disorders, prompting the need for more research and trials.</p>","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"54 4","pages":"675-687"},"PeriodicalIF":1.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045872/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18502/ijph.v54i4.18407","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Adropin, a peptide hormone has role in various various physiological processes, including metabolic regulation and cardiovascular health. This systematic review aimed to synthesize findings from observational studies on the involvement of adropin in neurological disorders and cognitive performance.
Methods: An extensive literature search was conducted across PubMed, Scopus, Web of Science, Embase, CORE, and Google Scholar using terms such as "adropin," "Neurological Disorders," "cognitive function," "Alzheimer's disease," "Parkinson's disease," "cognition," and "brain function." Studies published from 2020 to 2024 were selected and reviewed. The search and selection process adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Out of 127 screened articles, 5 met the inclusion criteria for this review.
Results: The combined research findings suggest a consistent link between decreased adropin levels and a range of neurological disorders and cognitive impairments. In particular, reduced adropin levels were seen in individuals with dementia, cognitive impairment, bipolar disorder, Parkinson's disease, and multiple sclerosis. These findings highlight adropin's potential role in modulating neurological health and cognitive function.
Conclusion: This systematic review underscores the importance of adropin in neurological health and its potential as a therapeutic agent. Based on the observed connections, adropin might serve as a new focus for treating neurological disorders, prompting the need for more research and trials.
背景：Adropin是一种多肽激素，在多种生理过程中发挥作用，包括代谢调节和心血管健康。本系统综述旨在综合有关adropin参与神经系统疾病和认知表现的观察性研究结果。方法：在PubMed、Scopus、Web of Science、Embase、CORE和谷歌Scholar上进行广泛的文献检索，使用“adropin”、“神经系统疾病”、“认知功能”、“阿尔茨海默病”、“帕金森病”、“认知”和“脑功能”等术语。选择并回顾了2020年至2024年发表的研究。搜索和选择过程遵循系统评价和荟萃分析（PRISMA）指南的首选报告项目。在127篇筛选的文章中，有5篇符合本综述的纳入标准。结果：综合研究结果表明，adropin水平下降与一系列神经系统疾病和认知障碍之间存在一致的联系。特别是，在痴呆、认知障碍、双相情感障碍、帕金森病和多发性硬化症患者中，adropin水平降低。这些发现强调了adropin在调节神经健康和认知功能方面的潜在作用。结论：本系统综述强调了adropin在神经系统健康中的重要性及其作为治疗药物的潜力。基于观察到的联系，adropin可能会成为治疗神经系统疾病的新焦点，促使需要更多的研究和试验。
期刊介绍：
Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.
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