{"title":"Application of oscillating field stimulation in the treatment of spinal cord injury: a systematic review and meta-analysis of preclinical studies.","authors":"Guanlong Wang, Luchun Xu, Jiaojiao Fan, Guozheng Jiang, Yushan Gao, Jiawei Song, Yukun Ma, Xing Yu, Yongdong Yang","doi":"10.1186/s12984-025-01632-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Oscillating Field Stimulation (OFS) is an emerging therapeutic approach for spinal cord injury (SCI) that is currently undergoing extensive investigation in preclinical in vivo studies. However, there has yet to be a comprehensive systematic review and meta-analysis of the existing literature. This systematic review and meta-analysis aims to evaluate the effectiveness of OFS technology in treating spinal cord injuries based on studies conducted with experimental animal models.</p><p><strong>Methods: </strong>A thorough search was performed across PubMed-MEDLINE, Embase, and Web of Science. Studies that were not in vivo preclinical research or were published in languages other than English were excluded. The SYRCLE tool was utilized to assess the risk of bias, and the extracted data underwent qualitative synthesis and meta-analysis.</p><p><strong>Results: </strong>Out of the 89 studies identified from the electronic databases, 8 fulfilled the inclusion criteria. Among these, 7 studies utilized a contusion model, while 1 employed a compression model. The application of OFS consistently resulted in significant enhancements in motor function scores compared to untreated SCI rats across all studies. This observed functional recovery correlated with histological improvements at the injury site. Although all studies were deemed to have a low risk of bias, some displayed incomplete reporting in specific areas.</p><p><strong>Conclusion: </strong>Our results indicate that OFS is a promising therapeutic approach for SCI, significantly enhancing functional recovery through multiple mechanisms. These include promoting nerve regeneration, aiding in myelin repair, and minimizing glial scarring. Future studies should concentrate on determining the optimal timing for OFS intervention, refining the electric field application methods, and investigating potential synergies with stem cell therapies. Thorough validation is essential before progressing to clinical applications.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"85"},"PeriodicalIF":5.2000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004646/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of NeuroEngineering and Rehabilitation","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1186/s12984-025-01632-w","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Oscillating Field Stimulation (OFS) is an emerging therapeutic approach for spinal cord injury (SCI) that is currently undergoing extensive investigation in preclinical in vivo studies. However, there has yet to be a comprehensive systematic review and meta-analysis of the existing literature. This systematic review and meta-analysis aims to evaluate the effectiveness of OFS technology in treating spinal cord injuries based on studies conducted with experimental animal models.
Methods: A thorough search was performed across PubMed-MEDLINE, Embase, and Web of Science. Studies that were not in vivo preclinical research or were published in languages other than English were excluded. The SYRCLE tool was utilized to assess the risk of bias, and the extracted data underwent qualitative synthesis and meta-analysis.
Results: Out of the 89 studies identified from the electronic databases, 8 fulfilled the inclusion criteria. Among these, 7 studies utilized a contusion model, while 1 employed a compression model. The application of OFS consistently resulted in significant enhancements in motor function scores compared to untreated SCI rats across all studies. This observed functional recovery correlated with histological improvements at the injury site. Although all studies were deemed to have a low risk of bias, some displayed incomplete reporting in specific areas.
Conclusion: Our results indicate that OFS is a promising therapeutic approach for SCI, significantly enhancing functional recovery through multiple mechanisms. These include promoting nerve regeneration, aiding in myelin repair, and minimizing glial scarring. Future studies should concentrate on determining the optimal timing for OFS intervention, refining the electric field application methods, and investigating potential synergies with stem cell therapies. Thorough validation is essential before progressing to clinical applications.
背景：振荡场刺激（OFS）是一种新兴的脊髓损伤（SCI）治疗方法，目前正在临床前体内研究中进行广泛的研究。然而，目前还没有对现有文献进行全面系统的回顾和荟萃分析。本系统综述和荟萃分析旨在基于实验动物模型的研究来评估OFS技术治疗脊髓损伤的有效性。方法：在PubMed-MEDLINE， Embase和Web of Science上进行彻底的搜索。非体内临床前研究或以非英语语言发表的研究被排除在外。使用sycle工具评估偏倚风险，提取的数据进行定性综合和荟萃分析。结果：从电子数据库中检索到的89篇研究中，有8篇符合纳入标准。其中7项研究采用挫伤模型，1项研究采用压缩模型。在所有研究中，与未治疗的脊髓损伤大鼠相比，OFS的应用一致导致运动功能评分显著增强。观察到的功能恢复与损伤部位的组织学改善相关。虽然所有的研究都被认为具有低偏倚风险，但有些研究在特定领域显示不完整的报告。结论：我们的研究结果表明，OFS是一种很有前景的治疗脊髓损伤的方法，通过多种机制显著促进功能恢复。这些包括促进神经再生，帮助髓磷脂修复，减少胶质瘢痕。未来的研究应集中在确定OFS干预的最佳时机，改进电场应用方法，并研究与干细胞治疗的潜在协同作用。在进行临床应用之前，彻底的验证是必不可少的。
期刊介绍：
Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.
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