Exploration of the association between 91 inflammatory proteins and immune thrombocytopenia: a two-sample Mendelian randomization analysis.

IF 1.8 4区医学 Q3 HEMATOLOGY

International Journal of Hematology Pub Date : 2025-09-01 Epub Date: 2025-04-22 DOI:10.1007/s12185-025-03987-1

Aihua Qin, Dan Liu, Heshan Tang, Jinqi Li, Liling Qiu, Baohua Qian, Yan Zang

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引用次数: 0

Abstract

Objective: This study aimed to explore the association between 91 circulating inflammatory proteins and immune thrombocytopenia (ITP) using Mendelian randomization (MR).

Methods: Data from genome-wide association studies (GWAS) on 91 inflammatory proteins were aggregated from the Olink Target platform, involving 14,824 participants. ITP data were sourced from the Integrative Epidemiology Unit OPEN GWAS project, which included 675 ITP patients and 488,749 controls. Mendelian randomization analysis was primarily conducted using inverse-variance weighting (IVW), supplemented by MR-Egger, weighted median, simple mode, and weighted mode. Pleiotropy and heterogeneity of the instrumental variables were assessed using the MR-Egger-intercept test and Cochran's Q test, with results visualized through scatter plots, funnel plots, and leave-one-out plots.

Results: The IVW method indicated an association between six specific circulating inflammatory proteins and ITP. Four proteins (CCL4, CXCL9, IL-12B, and SCF) were positively associated with ITP, while two proteins (IL-1α, TRANCE) showed a negative correlation.

Conclusion: The findings suggest a potential link between circulating inflammatory proteins and ITP, providing insights for future therapeutic strategies and biomarker identification.

Abstract Image

查看原文本刊更多论文

探索91种炎症蛋白与免疫性血小板减少症之间的关系：两样本孟德尔随机化分析。

目的：本研究旨在利用孟德尔随机化（MR）方法探讨91种循环炎症蛋白与免疫性血小板减少症（ITP）的关系。方法：从Olink Target平台收集91种炎症蛋白的全基因组关联研究（GWAS）数据，涉及14,824名参与者。ITP数据来自综合流行病学单位OPEN GWAS项目，该项目包括675名ITP患者和488,749名对照。孟德尔随机化分析以逆方差加权（IVW）为主，辅以MR-Egger、加权中位数、简单模式和加权模式。使用MR-Egger-intercept检验和Cochran’s Q检验评估工具变量的多效性和异质性，并通过散点图、漏斗图和遗漏图将结果可视化。结果：IVW法显示6种特异性循环炎症蛋白与ITP之间存在关联。4种蛋白（CCL4、CXCL9、IL-12B、SCF）与ITP呈正相关，2种蛋白（IL-1α、TRANCE）与ITP呈负相关。结论：研究结果表明循环炎症蛋白与ITP之间存在潜在联系，为未来的治疗策略和生物标志物鉴定提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hematology 医学-血液学

CiteScore

3.90

自引率

4.80%

发文量

223

审稿时长

6 months

期刊介绍： The International Journal of Hematology, the official journal of the Japanese Society of Hematology, has a long history of publishing leading research in hematology. The journal comprises articles that contribute to progress in research not only in basic hematology but also in clinical hematology, aiming to cover all aspects of this field, namely, erythrocytes, leukocytes and hematopoiesis, hemostasis, thrombosis and vascular biology, hematological malignancies, transplantation, and cell therapy. The expanded [Progress in Hematology] section integrates such relevant fields as the cell biology of stem cells and cancer cells, and clinical research in inflammation, cancer, and thrombosis. Reports on results of clinical trials are also included, thus contributing to the aim of fostering communication among researchers in the growing field of modern hematology. The journal provides the best of up-to-date information on modern hematology, presenting readers with high-impact, original work focusing on pivotal issues.